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pubmed-article:18589306pubmed:abstractText2-Methoxyestradiol (2ME2) is an endogenous metabolite of the human hormone, estrogen, which has been shown to possess anti-tumor activity. 2-Fluoroethoxyestradiol (2FEE2) and 2-fluoropropanoxyestradiol (2FPE2), novel analogs of 2-methoxyestradiol, were designed and synthesized to be utilized as F-18 radiotracers for positron emission tomography (PET), with which the bio-distribution and intratumoral accumulations of 2ME2 could be measured in vivo for potential translation to human use.lld:pubmed
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pubmed-article:18589306pubmed:articleTitleSyntheses and biological activities of novel 2-methoxyestradiol analogs, 2-fluoroethoxyestradiol and 2-fluoropropanoxyestradiol, and a radiosynthesis of 2-[(18)F]fluoroethoxyestradiol for positron emission tomography.lld:pubmed
pubmed-article:18589306pubmed:affiliationDepartment of Radiology, Emory University, Atlanta, GA 30322, USA.lld:pubmed
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pubmed-article:18589306pubmed:publicationTypeResearch Support, U.S. Gov't, Non-P.H.S.lld:pubmed
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