| pubmed-article:18587399 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18587399 | lifeskim:mentions | umls-concept:C0030498 | lld:lifeskim |
| pubmed-article:18587399 | lifeskim:mentions | umls-concept:C0014239 | lld:lifeskim |
| pubmed-article:18587399 | lifeskim:mentions | umls-concept:C0206430 | lld:lifeskim |
| pubmed-article:18587399 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:18587399 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:18587399 | lifeskim:mentions | umls-concept:C0040557 | lld:lifeskim |
| pubmed-article:18587399 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:18587399 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:18587399 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:18587399 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:18587399 | pubmed:dateCreated | 2008-7-22 | lld:pubmed |
| pubmed-article:18587399 | pubmed:abstractText | The parasite Toxoplasma gondii replicates in a specialized intracellular vacuole and causes disease in many species. Protection from toxoplasmosis is mediated by CD8(+) T cells, but the T. gondii antigens and host genes required for eliciting protective immunity are poorly defined. Here we identified GRA6, a polymorphic protein secreted in the parasitophorous vacuole, as the source of the immunodominant and protective decapeptide HF10 presented by the H-2L(d) major histocompatibility complex class I molecule. Presentation of the HF10-H-2L(d) ligand required proteolysis by ERAAP, the endoplasmic reticulum aminopeptidase associated with antigen processing. Consequently, expansion of protective CD8(+) T cell populations was impaired in T. gondii-infected ERAAP-deficient mice, which were more susceptible to toxoplasmosis. Thus, endoplasmic reticulum proteolysis is critical for eliciting protective immunity to a vacuolar parasite. | lld:pubmed |
| pubmed-article:18587399 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18587399 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18587399 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18587399 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18587399 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18587399 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18587399 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18587399 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18587399 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18587399 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18587399 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18587399 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18587399 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:18587399 | pubmed:issn | 1529-2916 | lld:pubmed |
| pubmed-article:18587399 | pubmed:author | pubmed-author:ShastriNilabh... | lld:pubmed |
| pubmed-article:18587399 | pubmed:author | pubmed-author:BlanchardNico... | lld:pubmed |
| pubmed-article:18587399 | pubmed:author | pubmed-author:RobeyEllen... | lld:pubmed |
| pubmed-article:18587399 | pubmed:author | pubmed-author:GonzalezFeder... | lld:pubmed |
| pubmed-article:18587399 | pubmed:author | pubmed-author:JonckerNathal... | lld:pubmed |
| pubmed-article:18587399 | pubmed:author | pubmed-author:SchaefferMari... | lld:pubmed |
| pubmed-article:18587399 | pubmed:author | pubmed-author:ChengTiffanyT | lld:pubmed |
| pubmed-article:18587399 | pubmed:author | pubmed-author:ShastriAnjali... | lld:pubmed |
| pubmed-article:18587399 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18587399 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:18587399 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18587399 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18587399 | pubmed:pagination | 937-44 | lld:pubmed |
| pubmed-article:18587399 | pubmed:dateRevised | 2011-3-18 | lld:pubmed |
| pubmed-article:18587399 | pubmed:meshHeading | pubmed-meshheading:18587399... | lld:pubmed |
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| pubmed-article:18587399 | pubmed:meshHeading | pubmed-meshheading:18587399... | lld:pubmed |
| pubmed-article:18587399 | pubmed:meshHeading | pubmed-meshheading:18587399... | lld:pubmed |
| pubmed-article:18587399 | pubmed:meshHeading | pubmed-meshheading:18587399... | lld:pubmed |
| pubmed-article:18587399 | pubmed:meshHeading | pubmed-meshheading:18587399... | lld:pubmed |
| pubmed-article:18587399 | pubmed:meshHeading | pubmed-meshheading:18587399... | lld:pubmed |
| pubmed-article:18587399 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18587399 | pubmed:articleTitle | Immunodominant, protective response to the parasite Toxoplasma gondii requires antigen processing in the endoplasmic reticulum. | lld:pubmed |
| pubmed-article:18587399 | pubmed:affiliation | Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA. nicolasblanchard@berkeley.edu | lld:pubmed |
| pubmed-article:18587399 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18587399 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:18587399 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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