| pubmed-article:18586027 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18586027 | lifeskim:mentions | umls-concept:C0105770 | lld:lifeskim |
| pubmed-article:18586027 | lifeskim:mentions | umls-concept:C0521447 | lld:lifeskim |
| pubmed-article:18586027 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:18586027 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:18586027 | lifeskim:mentions | umls-concept:C0475264 | lld:lifeskim |
| pubmed-article:18586027 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:18586027 | pubmed:issue | 15 | lld:pubmed |
| pubmed-article:18586027 | pubmed:dateCreated | 2008-9-1 | lld:pubmed |
| pubmed-article:18586027 | pubmed:abstractText | Beta-catenin plays a role in intracellular adhesion and regulating gene expression. The latter role is associated with its oncogenic properties. Phosphorylation of beta-catenin controls its intracellular expression but mechanism/s that regulates the nuclear localization of beta-catenin is unknown. We demonstrate that O-GlcNAc glycosylation (O-GlcNAcylation) of beta-catenin negatively regulates its levels in the nucleus. We show that normal prostate cells (PNT1A) have significantly higher amounts of O-GlcNAcylated beta-catenin compared to prostate cancer (CaP) cells. The total nuclear levels of beta-catenin are higher in the CaP cells than PNT1A but only a minimal fraction of the nuclear beta-catenin in the CaP cells are O-GlcNAcylated. Increasing the levels of O-GlcNAcylated beta-catenin in the CaP cells with PUGNAc (O- (2-acetamido-2-deoxy-d-gluco-pyranosylidene) amino-N-phenylcarbamate) treatment is associated with a progressive decrease in the levels of beta-catenin in the nucleus. TOPFlash reporter assay and mRNA expressions of beta-catenin's target genes indicate that O-GlcNAcylation of beta-catenin results in a decrease in its transcriptional activity. We define a novel modification of beta-catenin that regulates its nuclear localization and transcriptional function. | lld:pubmed |
| pubmed-article:18586027 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18586027 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18586027 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18586027 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18586027 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:18586027 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18586027 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18586027 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:18586027 | pubmed:issn | 1090-2422 | lld:pubmed |
| pubmed-article:18586027 | pubmed:author | pubmed-author:PersadSujataS | lld:pubmed |
| pubmed-article:18586027 | pubmed:author | pubmed-author:LeberBrianB | lld:pubmed |
| pubmed-article:18586027 | pubmed:author | pubmed-author:SayatRiaR | lld:pubmed |
| pubmed-article:18586027 | pubmed:author | pubmed-author:GrubacVanjaV | lld:pubmed |
| pubmed-article:18586027 | pubmed:author | pubmed-author:WiltshireLesl... | lld:pubmed |
| pubmed-article:18586027 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18586027 | pubmed:day | 10 | lld:pubmed |
| pubmed-article:18586027 | pubmed:volume | 314 | lld:pubmed |
| pubmed-article:18586027 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18586027 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18586027 | pubmed:pagination | 2774-87 | lld:pubmed |
| pubmed-article:18586027 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:18586027 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18586027 | pubmed:articleTitle | O-GlcNAc-glycosylation of beta-catenin regulates its nuclear localization and transcriptional activity. | lld:pubmed |
| pubmed-article:18586027 | pubmed:affiliation | Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada L8N 3Z5. | lld:pubmed |
| pubmed-article:18586027 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18586027 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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