| pubmed-article:18586001 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18586001 | lifeskim:mentions | umls-concept:C0282641 | lld:lifeskim |
| pubmed-article:18586001 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:18586001 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:18586001 | lifeskim:mentions | umls-concept:C0018767 | lld:lifeskim |
| pubmed-article:18586001 | lifeskim:mentions | umls-concept:C0004927 | lld:lifeskim |
| pubmed-article:18586001 | lifeskim:mentions | umls-concept:C2004454 | lld:lifeskim |
| pubmed-article:18586001 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:18586001 | lifeskim:mentions | umls-concept:C0085732 | lld:lifeskim |
| pubmed-article:18586001 | lifeskim:mentions | umls-concept:C1512167 | lld:lifeskim |
| pubmed-article:18586001 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:18586001 | lifeskim:mentions | umls-concept:C0231706 | lld:lifeskim |
| pubmed-article:18586001 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:18586001 | pubmed:dateCreated | 2008-7-30 | lld:pubmed |
| pubmed-article:18586001 | pubmed:abstractText | The circling (cir/cir) mouse is one of the murine models for human non-syndromic deafness DFNB6. The mice have abnormal circling behavior, suggesting a balanced disorder and profound deafness. The causative gene was transmembrane inner ear (tmie) gene of which the mutation is a 40-kb genomic deletion including tmie gene itself. In this study, tmie-overexpression trasngenic mice were established. Individuals with germline transmission have been mated with circling homozygous mutant mice (cir/cir) in order to produce the transgenic mutant mice (cir/cir-tg) as a gene therapy. After the genotyping, phenotypic analyses were performed so that the insertion of the new gene might compensate for the diseases such as hearing loss, circling behavior, or swimming inability. Some individuals exhibited complete recovery in their behavior and hearing but the others did not show any amelioration in behavior or hearing. Individual mice had very different levels of tmie transgene expression in the cochlea. These results clearly indicate that tmie protein plays an important role when the appropriate expression level of tmie was expressed in the inner ear. The protein levels were variable in each individual and these are thought to induce the differences in disease amelioration levels. | lld:pubmed |
| pubmed-article:18586001 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18586001 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18586001 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18586001 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18586001 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18586001 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:18586001 | pubmed:issn | 1090-2104 | lld:pubmed |
| pubmed-article:18586001 | pubmed:author | pubmed-author:HyunByung-Hwa... | lld:pubmed |
| pubmed-article:18586001 | pubmed:author | pubmed-author:LeeSanggyuS | lld:pubmed |
| pubmed-article:18586001 | pubmed:author | pubmed-author:KimBong SooBS | lld:pubmed |
| pubmed-article:18586001 | pubmed:author | pubmed-author:SoHong-SeobHS | lld:pubmed |
| pubmed-article:18586001 | pubmed:author | pubmed-author:ParkRaekilR | lld:pubmed |
| pubmed-article:18586001 | pubmed:author | pubmed-author:KimSung... | lld:pubmed |
| pubmed-article:18586001 | pubmed:author | pubmed-author:RyooZae... | lld:pubmed |
| pubmed-article:18586001 | pubmed:author | pubmed-author:ParkChannyC | lld:pubmed |
| pubmed-article:18586001 | pubmed:author | pubmed-author:KimMyoung... | lld:pubmed |
| pubmed-article:18586001 | pubmed:author | pubmed-author:ShinMi JungMJ | lld:pubmed |
| pubmed-article:18586001 | pubmed:author | pubmed-author:LeeJeong-HanJ... | lld:pubmed |
| pubmed-article:18586001 | pubmed:author | pubmed-author:YuDong HoonDH | lld:pubmed |
| pubmed-article:18586001 | pubmed:author | pubmed-author:KimHei JungHJ | lld:pubmed |
| pubmed-article:18586001 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18586001 | pubmed:day | 12 | lld:pubmed |
| pubmed-article:18586001 | pubmed:volume | 374 | lld:pubmed |
| pubmed-article:18586001 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18586001 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18586001 | pubmed:pagination | 17-21 | lld:pubmed |
| pubmed-article:18586001 | pubmed:meshHeading | pubmed-meshheading:18586001... | lld:pubmed |
| pubmed-article:18586001 | pubmed:meshHeading | pubmed-meshheading:18586001... | lld:pubmed |
| pubmed-article:18586001 | pubmed:meshHeading | pubmed-meshheading:18586001... | lld:pubmed |
| pubmed-article:18586001 | pubmed:meshHeading | pubmed-meshheading:18586001... | lld:pubmed |
| pubmed-article:18586001 | pubmed:meshHeading | pubmed-meshheading:18586001... | lld:pubmed |
| pubmed-article:18586001 | pubmed:meshHeading | pubmed-meshheading:18586001... | lld:pubmed |
| pubmed-article:18586001 | pubmed:meshHeading | pubmed-meshheading:18586001... | lld:pubmed |
| pubmed-article:18586001 | pubmed:meshHeading | pubmed-meshheading:18586001... | lld:pubmed |
| pubmed-article:18586001 | pubmed:meshHeading | pubmed-meshheading:18586001... | lld:pubmed |
| pubmed-article:18586001 | pubmed:meshHeading | pubmed-meshheading:18586001... | lld:pubmed |
| pubmed-article:18586001 | pubmed:meshHeading | pubmed-meshheading:18586001... | lld:pubmed |
| pubmed-article:18586001 | pubmed:meshHeading | pubmed-meshheading:18586001... | lld:pubmed |
| pubmed-article:18586001 | pubmed:meshHeading | pubmed-meshheading:18586001... | lld:pubmed |
| pubmed-article:18586001 | pubmed:meshHeading | pubmed-meshheading:18586001... | lld:pubmed |
| pubmed-article:18586001 | pubmed:meshHeading | pubmed-meshheading:18586001... | lld:pubmed |
| pubmed-article:18586001 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18586001 | pubmed:articleTitle | Ectopic expression of tmie transgene induces various recovery levels of behavior and hearing ability in the circling mouse. | lld:pubmed |
| pubmed-article:18586001 | pubmed:affiliation | School of Life Sciences and Biotechnology, College of Natural Sciences, Kyungpook National University, 1370 Sankyuk-dong, Buk-ku, Daegu 702-701, Republic of Korea. | lld:pubmed |
| pubmed-article:18586001 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18586001 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:20776 | entrezgene:pubmed | pubmed-article:18586001 | lld:entrezgene |
| entrez-gene:191577 | entrezgene:pubmed | pubmed-article:18586001 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:18586001 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18586001 | lld:pubmed |
