| pubmed-article:18585350 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18585350 | lifeskim:mentions | umls-concept:C0002395 | lld:lifeskim |
| pubmed-article:18585350 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:18585350 | lifeskim:mentions | umls-concept:C0019868 | lld:lifeskim |
| pubmed-article:18585350 | lifeskim:mentions | umls-concept:C1539418 | lld:lifeskim |
| pubmed-article:18585350 | lifeskim:mentions | umls-concept:C0683481 | lld:lifeskim |
| pubmed-article:18585350 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:18585350 | lifeskim:mentions | umls-concept:C1882417 | lld:lifeskim |
| pubmed-article:18585350 | lifeskim:mentions | umls-concept:C0962722 | lld:lifeskim |
| pubmed-article:18585350 | lifeskim:mentions | umls-concept:C1723136 | lld:lifeskim |
| pubmed-article:18585350 | lifeskim:mentions | umls-concept:C1869507 | lld:lifeskim |
| pubmed-article:18585350 | lifeskim:mentions | umls-concept:C2354310 | lld:lifeskim |
| pubmed-article:18585350 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:18585350 | pubmed:dateCreated | 2008-6-30 | lld:pubmed |
| pubmed-article:18585350 | pubmed:abstractText | Alzheimer's disease (AD) is a genetically heterogeneous disorder characterized by early hippocampal atrophy and cerebral amyloid-beta (Abeta) peptide deposition. Using TissueInfo to screen for genes preferentially expressed in the hippocampus and located in AD linkage regions, we identified a gene on 10q24.33 that we call CALHM1. We show that CALHM1 encodes a multipass transmembrane glycoprotein that controls cytosolic Ca(2+) concentrations and Abeta levels. CALHM1 homomultimerizes, shares strong sequence similarities with the selectivity filter of the NMDA receptor, and generates a large Ca(2+) conductance across the plasma membrane. Importantly, we determined that the CALHM1 P86L polymorphism (rs2986017) is significantly associated with AD in independent case-control studies of 3404 participants (allele-specific OR = 1.44, p = 2 x 10(-10)). We further found that the P86L polymorphism increases Abeta levels by interfering with CALHM1-mediated Ca(2+) permeability. We propose that CALHM1 encodes an essential component of a previously uncharacterized cerebral Ca(2+) channel that controls Abeta levels and susceptibility to late-onset AD. | lld:pubmed |
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| pubmed-article:18585350 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18585350 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18585350 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:18585350 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18585350 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:18585350 | pubmed:issn | 1097-4172 | lld:pubmed |
| pubmed-article:18585350 | pubmed:author | pubmed-author:ScarpiniElioE | lld:pubmed |
| pubmed-article:18585350 | pubmed:author | pubmed-author:FoskettJ... | lld:pubmed |
| pubmed-article:18585350 | pubmed:author | pubmed-author:DaviesPeterP | lld:pubmed |
| pubmed-article:18585350 | pubmed:author | pubmed-author:GalimbertiDan... | lld:pubmed |
| pubmed-article:18585350 | pubmed:author | pubmed-author:AmouyelPhilip... | lld:pubmed |
| pubmed-article:18585350 | pubmed:author | pubmed-author:MannDavidD | lld:pubmed |
| pubmed-article:18585350 | pubmed:author | pubmed-author:MarambaudPhil... | lld:pubmed |
| pubmed-article:18585350 | pubmed:author | pubmed-author:HannequinDidi... | lld:pubmed |
| pubmed-article:18585350 | pubmed:author | pubmed-author:CampionDomini... | lld:pubmed |
| pubmed-article:18585350 | pubmed:author | pubmed-author:CampagneFabie... | lld:pubmed |
| pubmed-article:18585350 | pubmed:author | pubmed-author:PasquierFlore... | lld:pubmed |
| pubmed-article:18585350 | pubmed:author | pubmed-author:LendonCorinne... | lld:pubmed |
| pubmed-article:18585350 | pubmed:author | pubmed-author:Dreses-Werrin... | lld:pubmed |
| pubmed-article:18585350 | pubmed:author | pubmed-author:KoppelJeremyJ | lld:pubmed |
| pubmed-article:18585350 | pubmed:author | pubmed-author:VaisHoriaH | lld:pubmed |
| pubmed-article:18585350 | pubmed:author | pubmed-author:LambertJean-C... | lld:pubmed |
| pubmed-article:18585350 | pubmed:author | pubmed-author:VingtdeuxValé... | lld:pubmed |
| pubmed-article:18585350 | pubmed:author | pubmed-author:ZhaoHaitianH | lld:pubmed |
| pubmed-article:18585350 | pubmed:author | pubmed-author:Rovelet-Lecru... | lld:pubmed |
| pubmed-article:18585350 | pubmed:author | pubmed-author:JainAnkitA | lld:pubmed |
| pubmed-article:18585350 | pubmed:author | pubmed-author:SiebertAdamA | lld:pubmed |
| pubmed-article:18585350 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18585350 | pubmed:day | 27 | lld:pubmed |
| pubmed-article:18585350 | pubmed:volume | 133 | lld:pubmed |
| pubmed-article:18585350 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18585350 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18585350 | pubmed:pagination | 1149-61 | lld:pubmed |
| pubmed-article:18585350 | pubmed:dateRevised | 2011-8-1 | lld:pubmed |
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