| pubmed-article:18569078 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18569078 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:18569078 | lifeskim:mentions | umls-concept:C0538674 | lld:lifeskim |
| pubmed-article:18569078 | lifeskim:mentions | umls-concept:C0162351 | lld:lifeskim |
| pubmed-article:18569078 | lifeskim:mentions | umls-concept:C0599946 | lld:lifeskim |
| pubmed-article:18569078 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:18569078 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:18569078 | pubmed:dateCreated | 2008-6-23 | lld:pubmed |
| pubmed-article:18569078 | pubmed:abstractText | Heme oxygenase (HO)-1 may have an important role in the resolution of T cell-mediated inflammation. The authors elucidated the role of the anti-inflammatory HO-1 in the pathogenesis of skin inflammation, using a mouse contact hypersensitivity (CHS) induced by 2,4-dinitrofluorobenzene (DNFB). Ear swelling was induced by challenge with DNFB, accompanied by infiltration of inflammatory cells in the challenged ear skin. DNFB challenge induced low levels of HO-1 mRNA and protein expression. Ear swelling induced by DNFB challenge was significantly reduced by topical treatment with cobalt protoporphyrin IX (CoPP), a HO-1 inducer, but exaggerated by blockage of HO-1 activity with tin protoporphyrin IX (SnPP), a HO-1 inhibitor. Similarly, the number of infiltrated cells in DNFB-challenged ear skin were reduced by CoPP but increased by SnPP. Our findings suggest that HO-1 plays an important role in CHS and is an important pharmacological target for the treatment of CHS. | lld:pubmed |
| pubmed-article:18569078 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18569078 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18569078 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18569078 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18569078 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18569078 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18569078 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18569078 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18569078 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18569078 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18569078 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18569078 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18569078 | pubmed:issn | 1532-2513 | lld:pubmed |
| pubmed-article:18569078 | pubmed:author | pubmed-author:PaeHyun-OckHO | lld:pubmed |
| pubmed-article:18569078 | pubmed:author | pubmed-author:ChaiKyu-YunKY | lld:pubmed |
| pubmed-article:18569078 | pubmed:author | pubmed-author:ChungHun-Taeg... | lld:pubmed |
| pubmed-article:18569078 | pubmed:author | pubmed-author:Ae HaYoungY | lld:pubmed |
| pubmed-article:18569078 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18569078 | pubmed:volume | 30 | lld:pubmed |
| pubmed-article:18569078 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18569078 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18569078 | pubmed:pagination | 207-16 | lld:pubmed |
| pubmed-article:18569078 | pubmed:dateRevised | 2009-5-14 | lld:pubmed |
| pubmed-article:18569078 | pubmed:meshHeading | pubmed-meshheading:18569078... | lld:pubmed |
| pubmed-article:18569078 | pubmed:meshHeading | pubmed-meshheading:18569078... | lld:pubmed |
| pubmed-article:18569078 | pubmed:meshHeading | pubmed-meshheading:18569078... | lld:pubmed |
| pubmed-article:18569078 | pubmed:meshHeading | pubmed-meshheading:18569078... | lld:pubmed |
| pubmed-article:18569078 | pubmed:meshHeading | pubmed-meshheading:18569078... | lld:pubmed |
| pubmed-article:18569078 | pubmed:meshHeading | pubmed-meshheading:18569078... | lld:pubmed |
| pubmed-article:18569078 | pubmed:meshHeading | pubmed-meshheading:18569078... | lld:pubmed |
| pubmed-article:18569078 | pubmed:meshHeading | pubmed-meshheading:18569078... | lld:pubmed |
| pubmed-article:18569078 | pubmed:meshHeading | pubmed-meshheading:18569078... | lld:pubmed |
| pubmed-article:18569078 | pubmed:meshHeading | pubmed-meshheading:18569078... | lld:pubmed |
| pubmed-article:18569078 | pubmed:meshHeading | pubmed-meshheading:18569078... | lld:pubmed |
| pubmed-article:18569078 | pubmed:meshHeading | pubmed-meshheading:18569078... | lld:pubmed |
| pubmed-article:18569078 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18569078 | pubmed:articleTitle | Heme oxygenase-1 attenuates contact hypersensitivity induced by 2,4-dinitrofluorobenzene in mice. | lld:pubmed |
| pubmed-article:18569078 | pubmed:affiliation | Department of Microbiology and Immunology, Wonkwang University School of Medicine, Iksan, Republic of Korea. | lld:pubmed |
| pubmed-article:18569078 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18569078 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:15368 | entrezgene:pubmed | pubmed-article:18569078 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:18569078 | lld:entrezgene |
