| pubmed-article:18566407 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18566407 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:18566407 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:18566407 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:18566407 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:18566407 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:18566407 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:18566407 | lifeskim:mentions | umls-concept:C1704410 | lld:lifeskim |
| pubmed-article:18566407 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:18566407 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:18566407 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:18566407 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:18566407 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:18566407 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:18566407 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:18566407 | pubmed:dateCreated | 2008-6-20 | lld:pubmed |
| pubmed-article:18566407 | pubmed:abstractText | Skeletal muscles account for more than 30% of the human body, yet mechanisms of immunological tolerance to this tissue remain mainly unexplored. To investigate the mechanisms of tolerance to muscle-specific proteins, we generated transgenic mice expressing the neo-autoantigen OVA exclusively in skeletal muscle (SM-OVA mice). SM-OVA mice were bred with OT-I or OT-II mice that possess a transgenic TCR specific for OVA peptides presented by MHC class I or class II, respectively. Tolerance to OVA did not involve clonal deletion, anergy or an increased regulatory T cell compartment. Rather, CD4+ T cell tolerance resulted from a mechanism of ignorance revealed by their response following OVA immunization. In marked contrast, CD8+ T cells exhibited a loss of OVA-specific cytotoxic activity associated with up-regulation of the immunoregulatory programmed death-1 molecule. Adoptive transfer experiments further showed that OVA expression in skeletal muscle was required to maintain this functional tolerance. These results establish a novel asymmetric model of immunological tolerance to muscle autoantigens involving Ag ignorance for CD4+ T cells, whereas muscle autoantigens recognized by CD8+ T cells results in blockade of their cytotoxic function. These observations may be helpful for understanding the breakage of tolerance in autoimmune muscle diseases. | lld:pubmed |
| pubmed-article:18566407 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18566407 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18566407 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:18566407 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18566407 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:18566407 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18566407 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18566407 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:18566407 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:18566407 | pubmed:author | pubmed-author:ArnoultChrist... | lld:pubmed |
| pubmed-article:18566407 | pubmed:author | pubmed-author:TronFrançoisF | lld:pubmed |
| pubmed-article:18566407 | pubmed:author | pubmed-author:BoyerOlivierO | lld:pubmed |
| pubmed-article:18566407 | pubmed:author | pubmed-author:AuthierFranço... | lld:pubmed |
| pubmed-article:18566407 | pubmed:author | pubmed-author:CalboSébastie... | lld:pubmed |
| pubmed-article:18566407 | pubmed:author | pubmed-author:DelagrèverieH... | lld:pubmed |
| pubmed-article:18566407 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18566407 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:18566407 | pubmed:volume | 181 | lld:pubmed |
| pubmed-article:18566407 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18566407 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18566407 | pubmed:pagination | 408-17 | lld:pubmed |
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| pubmed-article:18566407 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18566407 | pubmed:articleTitle | Functional tolerance of CD8+ T cells induced by muscle-specific antigen expression. | lld:pubmed |
| pubmed-article:18566407 | pubmed:affiliation | Institut National de la Santé et de la Recherche Médicale, Unité 905, University of Rouen, and Department of Immunology, Rouen University Hospital, Rouen, France. sebastien.calbo@univ-rouen.fr | lld:pubmed |
| pubmed-article:18566407 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18566407 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:12501 | entrezgene:pubmed | pubmed-article:18566407 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18566407 | lld:pubmed |
