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pubmed-article:18563907pubmed:abstractTextThe binding of a polymeric ligand to a cell surface receptor can promote its internalization. Methods to track and visualize multivalent ligands within a cell can give rise to new therapeutic strategies and illuminate signaling processes. We have used the features of the ring-opening metathesis polymerization (ROMP) to develop a general strategy for synthesizing multivalent ligands equipped with a latent fluorophore. The utility of ligands of this type is highlighted by visualizing multivalent antigen internalization in live B cells.lld:pubmed
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pubmed-article:18563907pubmed:articleTitleSynthesis of fluorogenic polymers for visualizing cellular internalization.lld:pubmed
pubmed-article:18563907pubmed:affiliationDepartment of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.lld:pubmed
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pubmed-article:18563907pubmed:publicationTypeResearch Support, U.S. Gov't, Non-P.H.S.lld:pubmed
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