| pubmed-article:18563666 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18563666 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:18563666 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:18563666 | lifeskim:mentions | umls-concept:C2340138 | lld:lifeskim |
| pubmed-article:18563666 | lifeskim:mentions | umls-concept:C0596290 | lld:lifeskim |
| pubmed-article:18563666 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:18563666 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:18563666 | lifeskim:mentions | umls-concept:C0018966 | lld:lifeskim |
| pubmed-article:18563666 | lifeskim:mentions | umls-concept:C0045137 | lld:lifeskim |
| pubmed-article:18563666 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:18563666 | pubmed:dateCreated | 2008-7-7 | lld:pubmed |
| pubmed-article:18563666 | pubmed:abstractText | We evaluated whether the antiproliferative effects of isoliquiritigenin (ISL) on rat hepatic stellate cells (HSCs) are related to the induction of heme oxygenase 1 (HO-1) expression. ISL significantly inhibited serum- or growth factor-induced HSC proliferation. The inhibition of platelet-derived growth factor (PDGF)-induced proliferation by ISL was associated with the mitogen-activated protein kinase and phosphatidylinositol 3-kinase-Akt-p70 (S6K) pathways. ISL induced the expression of HO-1 in HSCs. Using the chemical inhibitor tin protoporphyrin, we also found that the inhibitory action of ISL on PDGF-induced proliferation is mediated by HO-1. These data suggest that HO-1 expression is responsible for the antiproliferative effect of ISL on HSCs. | lld:pubmed |
| pubmed-article:18563666 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18563666 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18563666 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18563666 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18563666 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18563666 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18563666 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18563666 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18563666 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:18563666 | pubmed:issn | 0032-0943 | lld:pubmed |
| pubmed-article:18563666 | pubmed:author | pubmed-author:KimYoun-ChulY... | lld:pubmed |
| pubmed-article:18563666 | pubmed:author | pubmed-author:LeeSung HeeSH | lld:pubmed |
| pubmed-article:18563666 | pubmed:author | pubmed-author:WooSun WookSW | lld:pubmed |
| pubmed-article:18563666 | pubmed:author | pubmed-author:SohnDong... | lld:pubmed |
| pubmed-article:18563666 | pubmed:author | pubmed-author:KoGeonilG | lld:pubmed |
| pubmed-article:18563666 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18563666 | pubmed:volume | 74 | lld:pubmed |
| pubmed-article:18563666 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18563666 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18563666 | pubmed:pagination | 834-9 | lld:pubmed |
| pubmed-article:18563666 | pubmed:meshHeading | pubmed-meshheading:18563666... | lld:pubmed |
| pubmed-article:18563666 | pubmed:meshHeading | pubmed-meshheading:18563666... | lld:pubmed |
| pubmed-article:18563666 | pubmed:meshHeading | pubmed-meshheading:18563666... | lld:pubmed |
| pubmed-article:18563666 | pubmed:meshHeading | pubmed-meshheading:18563666... | lld:pubmed |
| pubmed-article:18563666 | pubmed:meshHeading | pubmed-meshheading:18563666... | lld:pubmed |
| pubmed-article:18563666 | pubmed:meshHeading | pubmed-meshheading:18563666... | lld:pubmed |
| pubmed-article:18563666 | pubmed:meshHeading | pubmed-meshheading:18563666... | lld:pubmed |
| pubmed-article:18563666 | pubmed:meshHeading | pubmed-meshheading:18563666... | lld:pubmed |
| pubmed-article:18563666 | pubmed:meshHeading | pubmed-meshheading:18563666... | lld:pubmed |
| pubmed-article:18563666 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18563666 | pubmed:articleTitle | Isoliquiritigenin inhibits cell proliferation by a heme oxygenase-dependent pathway in rat hepatic stellate cells. | lld:pubmed |
| pubmed-article:18563666 | pubmed:affiliation | National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, South Korea. | lld:pubmed |
| pubmed-article:18563666 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18563666 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
