| pubmed-article:18562627 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18562627 | lifeskim:mentions | umls-concept:C0123156 | lld:lifeskim |
| pubmed-article:18562627 | lifeskim:mentions | umls-concept:C1335238 | lld:lifeskim |
| pubmed-article:18562627 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:18562627 | lifeskim:mentions | umls-concept:C1334077 | lld:lifeskim |
| pubmed-article:18562627 | lifeskim:mentions | umls-concept:C1159884 | lld:lifeskim |
| pubmed-article:18562627 | lifeskim:mentions | umls-concept:C1709060 | lld:lifeskim |
| pubmed-article:18562627 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:18562627 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:18562627 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:18562627 | pubmed:dateCreated | 2008-9-1 | lld:pubmed |
| pubmed-article:18562627 | pubmed:abstractText | We previously identified the small molecule harmine as a regulator of peroxisome proliferator activated-receptor gamma (PPARgamma) and adipocyte differentiation. In an effort to identify signaling pathways mediating harmine's effects, we performed transcriptional profiling of 3T3-F442A preadipocytes. Inhibitor of DNA biding 2 (Id2) was identified as a gene rapidly induced by harmine but not by PPARgamma agonists. Id2 is also induced in 3T3-L1 preadipocytes treated with dexamethasone, 3-isobutyl-1-methylxanthine, and insulin, suggesting that Id2 regulation is a common feature of the adipogenic program. Stable overexpression of Id2 in preadipocytes promotes expression of PPARgamma and enhances morphological differentiation and lipid accumulation. Conversely, small interfering RNA-mediated knockdown of Id2 antagonizes adipocyte differentiation. Mice lacking Id2 expression display reduced adiposity, and embryonic fibroblasts derived from these mice exhibit reduced PPARgamma expression and a diminished capacity for adipocyte differentiation. Finally, Id2 expression is elevated in adipose tissues of obese mice and humans. These results outline a role for Id2 in the modulation of PPARgamma expression and adipogenesis and underscore the utility of adipogenic small molecules as tools to dissect adipocyte biology. | lld:pubmed |
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| pubmed-article:18562627 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:18562627 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:18562627 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18562627 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:18562627 | pubmed:issn | 0888-8809 | lld:pubmed |
| pubmed-article:18562627 | pubmed:author | pubmed-author:TontonozPeter... | lld:pubmed |
| pubmed-article:18562627 | pubmed:author | pubmed-author:MacDougaldOrm... | lld:pubmed |
| pubmed-article:18562627 | pubmed:author | pubmed-author:WakiHironoriH | lld:pubmed |
| pubmed-article:18562627 | pubmed:author | pubmed-author:GoldrathAnand... | lld:pubmed |
| pubmed-article:18562627 | pubmed:author | pubmed-author:ParkKye WonKW | lld:pubmed |
| pubmed-article:18562627 | pubmed:author | pubmed-author:KangSonaS | lld:pubmed |
| pubmed-article:18562627 | pubmed:author | pubmed-author:VillanuevaCla... | lld:pubmed |
| pubmed-article:18562627 | pubmed:author | pubmed-author:HongCynthiaC | lld:pubmed |
| pubmed-article:18562627 | pubmed:author | pubmed-author:MonticelliLau... | lld:pubmed |
| pubmed-article:18562627 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18562627 | pubmed:volume | 22 | lld:pubmed |
| pubmed-article:18562627 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18562627 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18562627 | pubmed:pagination | 2038-48 | lld:pubmed |
| pubmed-article:18562627 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:18562627 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18562627 | pubmed:articleTitle | Inhibitor of DNA binding 2 is a small molecule-inducible modulator of peroxisome proliferator-activated receptor-gamma expression and adipocyte differentiation. | lld:pubmed |
| pubmed-article:18562627 | pubmed:affiliation | Howard Hughes Medical Institute, University of California, Los Angeles, California 90095, USA. | lld:pubmed |
| pubmed-article:18562627 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18562627 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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