| pubmed-article:18562553 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18562553 | lifeskim:mentions | umls-concept:C0027793 | lld:lifeskim |
| pubmed-article:18562553 | lifeskim:mentions | umls-concept:C0011570 | lld:lifeskim |
| pubmed-article:18562553 | lifeskim:mentions | umls-concept:C2700592 | lld:lifeskim |
| pubmed-article:18562553 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:18562553 | lifeskim:mentions | umls-concept:C1265875 | lld:lifeskim |
| pubmed-article:18562553 | lifeskim:mentions | umls-concept:C0234112 | lld:lifeskim |
| pubmed-article:18562553 | lifeskim:mentions | umls-concept:C1882911 | lld:lifeskim |
| pubmed-article:18562553 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:18562553 | pubmed:dateCreated | 2008-8-13 | lld:pubmed |
| pubmed-article:18562553 | pubmed:abstractText | Serotonin can produce multiple, contradictory modulatory effects on strength of synaptic transmission in both vertebrate and invertebrate nerve circuits. In crayfish, serotonin (5-HT) can both facilitate and depress transmission to lateral giant escape command neurons; however, which effect is manifest during application, as well as the sign and duration of effects that may continue long after 5-HT washout, may depend on history of application as well as on concentration. We report that protein kinase A (PKA) signaling is essential to the production of facilitation but depression is mediated by non-cAMP/PKA signaling pathways. However, we unexpectedly found that PKA activity is essential for the decay of depression when serotonin is washed out. This, and evidence from the effects of a variety of serotonin application regimens, suggest that facilitatory and depressive states coexist and compete and that the decay of each is dependent on stimulation by the other. A computational model that incorporates these assumptions can account for and rationalize the varied effects of a wide range of serotonin application regimens. | lld:pubmed |
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| pubmed-article:18562553 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18562553 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18562553 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18562553 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:18562553 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18562553 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:18562553 | pubmed:issn | 0022-3077 | lld:pubmed |
| pubmed-article:18562553 | pubmed:author | pubmed-author:TaylorKarenK | lld:pubmed |
| pubmed-article:18562553 | pubmed:author | pubmed-author:KrasneFrankli... | lld:pubmed |
| pubmed-article:18562553 | pubmed:author | pubmed-author:LeeSun Hee... | lld:pubmed |
| pubmed-article:18562553 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18562553 | pubmed:volume | 100 | lld:pubmed |
| pubmed-article:18562553 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18562553 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18562553 | pubmed:pagination | 1113-26 | lld:pubmed |
| pubmed-article:18562553 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:18562553 | pubmed:meshHeading | pubmed-meshheading:18562553... | lld:pubmed |
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| pubmed-article:18562553 | pubmed:meshHeading | pubmed-meshheading:18562553... | lld:pubmed |
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| pubmed-article:18562553 | pubmed:meshHeading | pubmed-meshheading:18562553... | lld:pubmed |
| pubmed-article:18562553 | pubmed:meshHeading | pubmed-meshheading:18562553... | lld:pubmed |
| pubmed-article:18562553 | pubmed:meshHeading | pubmed-meshheading:18562553... | lld:pubmed |
| pubmed-article:18562553 | pubmed:meshHeading | pubmed-meshheading:18562553... | lld:pubmed |
| pubmed-article:18562553 | pubmed:meshHeading | pubmed-meshheading:18562553... | lld:pubmed |
| pubmed-article:18562553 | pubmed:meshHeading | pubmed-meshheading:18562553... | lld:pubmed |
| pubmed-article:18562553 | pubmed:meshHeading | pubmed-meshheading:18562553... | lld:pubmed |
| pubmed-article:18562553 | pubmed:meshHeading | pubmed-meshheading:18562553... | lld:pubmed |
| pubmed-article:18562553 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18562553 | pubmed:articleTitle | Reciprocal stimulation of decay between serotonergic facilitation and depression of synaptic transmission. | lld:pubmed |
| pubmed-article:18562553 | pubmed:affiliation | Department of Psychology, UCLA, Los Angeles, CA 90095, USA. | lld:pubmed |
| pubmed-article:18562553 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18562553 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:18562553 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
