| pubmed-article:18559970 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18559970 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:18559970 | lifeskim:mentions | umls-concept:C0031809 | lld:lifeskim |
| pubmed-article:18559970 | lifeskim:mentions | umls-concept:C0086692 | lld:lifeskim |
| pubmed-article:18559970 | lifeskim:mentions | umls-concept:C0027831 | lld:lifeskim |
| pubmed-article:18559970 | lifeskim:mentions | umls-concept:C0024485 | lld:lifeskim |
| pubmed-article:18559970 | lifeskim:mentions | umls-concept:C1449699 | lld:lifeskim |
| pubmed-article:18559970 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:18559970 | pubmed:dateCreated | 2008-7-23 | lld:pubmed |
| pubmed-article:18559970 | pubmed:abstractText | People with neurofibromatosis 1 (NF1) have multiple benign neurofibromas and a 10% lifetime risk of developing malignant peripheral nerve sheath tumors (MPNSTs). Most MPNSTs develop from benign plexiform neurofibromas, so the burden of benign tumors may be a risk factor for developing MPNST. We studied 13 NF1 patients with MPNSTs and 26 age- and sex-matched controls (NF1 patients who did not have MPNSTs) with detailed clinical examinations and whole-body MRI to characterize their body burden of internal benign neurofibromas. Internal plexiform neurofibromas were identified in 22 (56%) of the 39 NF1 patients studied. All six of the NF1 patients with MPNSTs under 30 years of age had neurofibromas visualized on whole-body MRI, compared to only 3 of 11 matched NF1 controls under age 30 (p < 0.05). Both the median number of plexiform neurofibromas (p < 0.05) and the median neurofibroma volume (p < 0.01) on whole-body MRI were significantly greater among MPNST patients younger than 30 years of age than among controls. No significant differences in whole-body MRI findings were observed between NF1 patients with MPNSTs and controls who were 30 years of age or older. Whole-body MRI of NF1 patients allows assessment of the burden of internal neurofibromas, most of which are not apparent on physical examination. Whole-body imaging of young NF1 patients may allow those at highest risk for developing MPNST to be identified early in life. Close surveillance of these high-risk patients may permit earlier diagnosis and more effective treatment of MPNSTs that develop. | lld:pubmed |
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| pubmed-article:18559970 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18559970 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18559970 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18559970 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18559970 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:18559970 | pubmed:issn | 1522-8517 | lld:pubmed |
| pubmed-article:18559970 | pubmed:author | pubmed-author:KluweLanL | lld:pubmed |
| pubmed-article:18559970 | pubmed:author | pubmed-author:MautnerVictor... | lld:pubmed |
| pubmed-article:18559970 | pubmed:author | pubmed-author:FriedmanJan... | lld:pubmed |
| pubmed-article:18559970 | pubmed:author | pubmed-author:WidemannBrigi... | lld:pubmed |
| pubmed-article:18559970 | pubmed:author | pubmed-author:DombiEvaE | lld:pubmed |
| pubmed-article:18559970 | pubmed:author | pubmed-author:FünstererCars... | lld:pubmed |
| pubmed-article:18559970 | pubmed:author | pubmed-author:AsuagborFlore... | lld:pubmed |
| pubmed-article:18559970 | pubmed:author | pubmed-author:WenzelRalfR | lld:pubmed |
| pubmed-article:18559970 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18559970 | pubmed:volume | 10 | lld:pubmed |
| pubmed-article:18559970 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18559970 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18559970 | pubmed:pagination | 593-8 | lld:pubmed |
| pubmed-article:18559970 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:18559970 | pubmed:meshHeading | pubmed-meshheading:18559970... | lld:pubmed |
| pubmed-article:18559970 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18559970 | pubmed:articleTitle | Assessment of benign tumor burden by whole-body MRI in patients with neurofibromatosis 1. | lld:pubmed |
| pubmed-article:18559970 | pubmed:affiliation | Department of Maxillofacial Surgery, University Hospital Eppendorf, Hamburg, Germany. | lld:pubmed |
| pubmed-article:18559970 | pubmed:publicationType | Journal Article | lld:pubmed |
