| pubmed-article:18559537 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18559537 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:18559537 | lifeskim:mentions | umls-concept:C0006826 | lld:lifeskim |
| pubmed-article:18559537 | lifeskim:mentions | umls-concept:C0074825 | lld:lifeskim |
| pubmed-article:18559537 | lifeskim:mentions | umls-concept:C0003316 | lld:lifeskim |
| pubmed-article:18559537 | lifeskim:mentions | umls-concept:C0020964 | lld:lifeskim |
| pubmed-article:18559537 | lifeskim:mentions | umls-concept:C1509144 | lld:lifeskim |
| pubmed-article:18559537 | lifeskim:mentions | umls-concept:C0337051 | lld:lifeskim |
| pubmed-article:18559537 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:18559537 | pubmed:dateCreated | 2008-6-18 | lld:pubmed |
| pubmed-article:18559537 | pubmed:abstractText | Recent studies have shown the importance of helper CD4 T cells in initiating and sustaining tumor-specific CD8 T-cell immunity. This has paved the way for identifying MHC class II epitopes that could be incorporated into class I-based vaccines. In this study, the goal was to identify an HLA-DR-degenerate epitope pool derived from insulin-like growth factor binding protein 2 (IGFBP-2). IGFBP-2, a regulator of insulin-like growth factor action, is overexpressed in the majority of breast and ovarian cancers. Using algorithms, we predicted 29 HLA-DR1-binding epitopes. Binding assays targeting 15 different HLA-DRs revealed that 10 epitopes were degenerate, binding to at least four different HLA-DR variants. An IFN-gamma enzyme-linked immunosorbent spot assay was used to assess immunity to these 10 epitopes in 48 patients with either breast or ovarian cancer and 18 controls. Elevated T-cell immunity in patients was detected in 4 of the 10 epitopes (IGFBP2.17, IGFBP2.22, IGFBP2.249, and IGFBP2.293). The cumulative T-cell frequency of these four epitopes was elevated in patients relative to controls. All four peptides are naturally processed and presented to CD4 T-cells. The degenerate pool of peptides covers nearly 80% of patients and may be useful for augmenting CD4 T-cell immunity in patients undergoing immunization. | lld:pubmed |
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| pubmed-article:18559537 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18559537 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18559537 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:18559537 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18559537 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:18559537 | pubmed:issn | 1538-7445 | lld:pubmed |
| pubmed-article:18559537 | pubmed:author | pubmed-author:KnutsonKeith... | lld:pubmed |
| pubmed-article:18559537 | pubmed:author | pubmed-author:DisisMary LML | lld:pubmed |
| pubmed-article:18559537 | pubmed:author | pubmed-author:HartmannLynn... | lld:pubmed |
| pubmed-article:18559537 | pubmed:author | pubmed-author:WettsteinPete... | lld:pubmed |
| pubmed-article:18559537 | pubmed:author | pubmed-author:MaurerMatthew... | lld:pubmed |
| pubmed-article:18559537 | pubmed:author | pubmed-author:IshiokaGlennG | lld:pubmed |
| pubmed-article:18559537 | pubmed:author | pubmed-author:BeebeMelanieM | lld:pubmed |
| pubmed-article:18559537 | pubmed:author | pubmed-author:KalliKimberly... | lld:pubmed |
| pubmed-article:18559537 | pubmed:author | pubmed-author:KrcoChristoph... | lld:pubmed |
| pubmed-article:18559537 | pubmed:author | pubmed-author:YuChaoC | lld:pubmed |
| pubmed-article:18559537 | pubmed:author | pubmed-author:FikesJohn DJD | lld:pubmed |
| pubmed-article:18559537 | pubmed:author | pubmed-author:ErskineCourtn... | lld:pubmed |
| pubmed-article:18559537 | pubmed:author | pubmed-author:GoodmanKarinK | lld:pubmed |
| pubmed-article:18559537 | pubmed:author | pubmed-author:JohnsonElliot... | lld:pubmed |
| pubmed-article:18559537 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18559537 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:18559537 | pubmed:volume | 68 | lld:pubmed |
| pubmed-article:18559537 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18559537 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18559537 | pubmed:pagination | 4893-901 | lld:pubmed |
