| pubmed-article:18559480 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18559480 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:18559480 | lifeskim:mentions | umls-concept:C0011304 | lld:lifeskim |
| pubmed-article:18559480 | lifeskim:mentions | umls-concept:C0596988 | lld:lifeskim |
| pubmed-article:18559480 | lifeskim:mentions | umls-concept:C1421944 | lld:lifeskim |
| pubmed-article:18559480 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:18559480 | lifeskim:mentions | umls-concept:C0031610 | lld:lifeskim |
| pubmed-article:18559480 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:18559480 | pubmed:dateCreated | 2008-6-18 | lld:pubmed |
| pubmed-article:18559480 | pubmed:abstractText | Lipids play crucial roles in many aspects of glial cell biology, affecting processes ranging from myelin membrane biosynthesis to axo-glial interactions. In order to study the role of lipid metabolism in myelinating glial cells, we specifically deleted in Schwann cells the Lpin1 gene, which encodes the Mg2+-dependent phosphatidate phosphatase (PAP1) enzyme necessary for normal triacylglycerol biosynthesis. The affected animals developed pronounced peripheral neuropathy characterized by myelin degradation, Schwann cell dedifferentiation and proliferation, and a reduction in nerve conduction velocity. The observed demyelination is mediated by endoneurial accumulation of the substrate of the PAP1 enzyme, phosphatidic acid (PA). In addition, we show that PA is a potent activator of the MEK-Erk pathway in Schwann cells, and that this activation is required for PA-induced demyelination. Our results therefore reveal a surprising role for PA in Schwann cell fate determination and provide evidence of a direct link between diseases affecting lipid metabolism and abnormal Schwann cell function. | lld:pubmed |
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| pubmed-article:18559480 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18559480 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18559480 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:18559480 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18559480 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:18559480 | pubmed:issn | 0890-9369 | lld:pubmed |
| pubmed-article:18559480 | pubmed:author | pubmed-author:CarmanGeorge... | lld:pubmed |
| pubmed-article:18559480 | pubmed:author | pubmed-author:GrèsSandraS | lld:pubmed |
| pubmed-article:18559480 | pubmed:author | pubmed-author:HanGil-SooGS | lld:pubmed |
| pubmed-article:18559480 | pubmed:author | pubmed-author:ChrastRomanR | lld:pubmed |
| pubmed-article:18559480 | pubmed:author | pubmed-author:VerheijenMark... | lld:pubmed |
| pubmed-article:18559480 | pubmed:author | pubmed-author:HendriksWilli... | lld:pubmed |
| pubmed-article:18559480 | pubmed:author | pubmed-author:Saulnier-Blac... | lld:pubmed |
| pubmed-article:18559480 | pubmed:author | pubmed-author:NadraKarimK | lld:pubmed |
| pubmed-article:18559480 | pubmed:author | pubmed-author:de Preux... | lld:pubmed |
| pubmed-article:18559480 | pubmed:author | pubmed-author:MédardJean-Ja... | lld:pubmed |
| pubmed-article:18559480 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18559480 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:18559480 | pubmed:volume | 22 | lld:pubmed |
| pubmed-article:18559480 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18559480 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18559480 | pubmed:pagination | 1647-61 | lld:pubmed |
| pubmed-article:18559480 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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