| pubmed-article:18554389 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18554389 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:18554389 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:18554389 | lifeskim:mentions | umls-concept:C0021852 | lld:lifeskim |
| pubmed-article:18554389 | lifeskim:mentions | umls-concept:C1326912 | lld:lifeskim |
| pubmed-article:18554389 | lifeskim:mentions | umls-concept:C0001721 | lld:lifeskim |
| pubmed-article:18554389 | pubmed:dateCreated | 2008-7-1 | lld:pubmed |
| pubmed-article:18554389 | pubmed:abstractText | Alterations in gene splicing occur in human sporadic colorectal cancer (CRC) and may contribute to tumour progression. The K-ras proto-oncogene encodes two splice variants, K-ras 4A and 4B, and K-ras activating mutations which jointly affect both isoforms are prevalent in CRC. Past studies have established that splicing of both the K-ras oncogene and proto-oncogene is altered in CRC in favour of K-ras 4B. The present study addressed whether the K-Ras 4A proto-oncoprotein can suppress tumour development in the absence of its oncogenic allele, utilising the ApcMin/+ (Min) mouse that spontaneously develops intestinal tumours that do not harbour K-ras activating mutations, and the K-rastmDelta4A/tmDelta4A mouse that can express the K-ras 4B splice variant only. By this means tumorigenesis in the small intestine was compared between ApcMin/+, K-ras+/+ and ApcMin/+, K-rastmDelta4A/tmDelta4A mice that can, and cannot, express the K-ras 4A proto-oncoprotein respectively. | lld:pubmed |
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| pubmed-article:18554389 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18554389 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18554389 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:18554389 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18554389 | pubmed:issn | 1471-230X | lld:pubmed |
| pubmed-article:18554389 | pubmed:author | pubmed-author:WalkerMarionM | lld:pubmed |
| pubmed-article:18554389 | pubmed:author | pubmed-author:HooperMartin... | lld:pubmed |
| pubmed-article:18554389 | pubmed:author | pubmed-author:PatekCharles... | lld:pubmed |
| pubmed-article:18554389 | pubmed:author | pubmed-author:SansomOwen... | lld:pubmed |
| pubmed-article:18554389 | pubmed:author | pubmed-author:ArendsMark... | lld:pubmed |
| pubmed-article:18554389 | pubmed:author | pubmed-author:LuoFeijunF | lld:pubmed |
| pubmed-article:18554389 | pubmed:author | pubmed-author:BerryRachel... | lld:pubmed |
| pubmed-article:18554389 | pubmed:author | pubmed-author:DevenneyPaul... | lld:pubmed |
| pubmed-article:18554389 | pubmed:author | pubmed-author:RoseLorraineL | lld:pubmed |
| pubmed-article:18554389 | pubmed:author | pubmed-author:LawrenceNicol... | lld:pubmed |
| pubmed-article:18554389 | pubmed:author | pubmed-author:RidgwayRachel... | lld:pubmed |
| pubmed-article:18554389 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18554389 | pubmed:volume | 8 | lld:pubmed |
| pubmed-article:18554389 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18554389 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18554389 | pubmed:pagination | 24 | lld:pubmed |
| pubmed-article:18554389 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:18554389 | pubmed:meshHeading | pubmed-meshheading:18554389... | lld:pubmed |
| pubmed-article:18554389 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18554389 | pubmed:articleTitle | The pro-apoptotic K-Ras 4A proto-oncoprotein does not affect tumorigenesis in the ApcMin/+ mouse small intestine. | lld:pubmed |
| pubmed-article:18554389 | pubmed:affiliation | Sir Alastair Currie Cancer Research UK Laboratories, Molecular Medicine Centre, The University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK. charles.patek@hotmail.com | lld:pubmed |
| pubmed-article:18554389 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18554389 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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