| pubmed-article:18550162 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18550162 | lifeskim:mentions | umls-concept:C0034493 | lld:lifeskim |
| pubmed-article:18550162 | lifeskim:mentions | umls-concept:C1179873 | lld:lifeskim |
| pubmed-article:18550162 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:18550162 | lifeskim:mentions | umls-concept:C0205359 | lld:lifeskim |
| pubmed-article:18550162 | lifeskim:mentions | umls-concept:C0376249 | lld:lifeskim |
| pubmed-article:18550162 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:18550162 | pubmed:dateCreated | 2008-11-10 | lld:pubmed |
| pubmed-article:18550162 | pubmed:abstractText | Spontaneous Ca(2+) release from the sarcoplasmic reticulum (SR) appears to play an important role in cardiac sinoatrial node pacemaking. However, comparatively little is known about the role of intracellular Ca(2+) in the atrioventricular node (AVN). Intracellular Ca(2+) was therefore monitored in cells isolated from the rabbit AVN, using fluo-3 in conjunction with confocal microscopy. These cells displayed spontaneous Ca(2+) transients and action potentials. Ca(2+) transients were normally preceded by a small, slow increase (ramp) of intracellular Ca(2+) which was sometimes, but not always, accompanied by Ca(2+) sparks. During the Ca(2+) transient, intracellular [Ca(2+)] increased initially at the cell periphery and propagated inhomogeneously to the cell centre. The rate of spontaneous activity was decreased by ryanodine (1muM) and increased by isoprenaline (500nM); these changes were accompanied by a decrease and increase, respectively, in the slope of the preceding Ca(2+) ramp, with no significant change in Ca(2+) spark characteristics. Rapidly reducing bathing [Na(+)] inhibited spontaneous activity. These findings provide the first information on Ca(2+) handling at the sub-cellular level and link cellular Ca(2+) cycling to the genesis of spontaneous activity in the AVN. | lld:pubmed |
| pubmed-article:18550162 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18550162 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18550162 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18550162 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18550162 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18550162 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18550162 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18550162 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18550162 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18550162 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:18550162 | pubmed:issn | 1532-1991 | lld:pubmed |
| pubmed-article:18550162 | pubmed:author | pubmed-author:SmithG LGL | lld:pubmed |
| pubmed-article:18550162 | pubmed:author | pubmed-author:JonesS KSK | lld:pubmed |
| pubmed-article:18550162 | pubmed:author | pubmed-author:ChengHH | lld:pubmed |
| pubmed-article:18550162 | pubmed:author | pubmed-author:OrchardC HCH | lld:pubmed |
| pubmed-article:18550162 | pubmed:author | pubmed-author:RidleyJ MJM | lld:pubmed |
| pubmed-article:18550162 | pubmed:author | pubmed-author:HancoxJ CJC | lld:pubmed |
| pubmed-article:18550162 | pubmed:author | pubmed-author:HarrisonO JOJ | lld:pubmed |
| pubmed-article:18550162 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18550162 | pubmed:volume | 44 | lld:pubmed |
| pubmed-article:18550162 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18550162 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18550162 | pubmed:pagination | 580-91 | lld:pubmed |
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| pubmed-article:18550162 | pubmed:meshHeading | pubmed-meshheading:18550162... | lld:pubmed |
| pubmed-article:18550162 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18550162 | pubmed:articleTitle | Spontaneous frequency of rabbit atrioventricular node myocytes depends on SR function. | lld:pubmed |
| pubmed-article:18550162 | pubmed:affiliation | Department of Physiology & Pharmacology, Cardiovascular Research Laboratories, Bristol Heart Institute, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK. | lld:pubmed |
| pubmed-article:18550162 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18550162 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18550162 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18550162 | lld:pubmed |
