| pubmed-article:18548087 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18548087 | lifeskim:mentions | umls-concept:C0022688 | lld:lifeskim |
| pubmed-article:18548087 | lifeskim:mentions | umls-concept:C0596402 | lld:lifeskim |
| pubmed-article:18548087 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:18548087 | lifeskim:mentions | umls-concept:C0079189 | lld:lifeskim |
| pubmed-article:18548087 | lifeskim:mentions | umls-concept:C1442161 | lld:lifeskim |
| pubmed-article:18548087 | lifeskim:mentions | umls-concept:C1254042 | lld:lifeskim |
| pubmed-article:18548087 | lifeskim:mentions | umls-concept:C0079411 | lld:lifeskim |
| pubmed-article:18548087 | lifeskim:mentions | umls-concept:C0205088 | lld:lifeskim |
| pubmed-article:18548087 | lifeskim:mentions | umls-concept:C1881379 | lld:lifeskim |
| pubmed-article:18548087 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:18548087 | pubmed:dateCreated | 2008-9-4 | lld:pubmed |
| pubmed-article:18548087 | pubmed:abstractText | Class IA phosphotidylinositol-3-kinases (PI3Ks) are a family of p85/p110 heterodimeric lipid kinases that are important in regulating signaling events in B and T cells. However, their role in natural killer (NK) cells is not understood. Here, using mice that lack the regulatory p85alpha subunit and its alternatively spliced variants p55alpha/p50alpha (collectively termed as p85alpha(-/-)), we defined the role of PI3K in NK cell development and function. p85alpha(-/-) mice had impaired lineage commitment leading to reduced NK cellularity in the bone marrow and liver. p85alpha(-/-) NK cells showed a defective Ly49 subset specification and a decreased expression of CD43. Lack of p85alpha severely reduced the NK-mediated cytotoxicity against tumor cells representing 'induced-self' and 'missing-self'. More importantly, NKG2D and NK1.1 receptor-mediated cytokine and chemokine generation was significantly compromised in p85alpha(-/-) NK cells. These results reveal a previously unrecognized role of p85alpha in the development, terminal maturation, cytokine/chemokine generation and tumor clearance of NK cells. | lld:pubmed |
| pubmed-article:18548087 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18548087 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18548087 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18548087 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18548087 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18548087 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18548087 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18548087 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18548087 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18548087 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18548087 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18548087 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18548087 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18548087 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18548087 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18548087 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18548087 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18548087 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:18548087 | pubmed:issn | 1476-5470 | lld:pubmed |
| pubmed-article:18548087 | pubmed:author | pubmed-author:WangDD | lld:pubmed |
| pubmed-article:18548087 | pubmed:author | pubmed-author:DayHH | lld:pubmed |
| pubmed-article:18548087 | pubmed:author | pubmed-author:MalarkannanSS | lld:pubmed |
| pubmed-article:18548087 | pubmed:author | pubmed-author:AwasthiAA | lld:pubmed |
| pubmed-article:18548087 | pubmed:author | pubmed-author:WenRR | lld:pubmed |
| pubmed-article:18548087 | pubmed:author | pubmed-author:SamarakoonAA | lld:pubmed |
| pubmed-article:18548087 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18548087 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:18548087 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18548087 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18548087 | pubmed:pagination | 522-35 | lld:pubmed |
| pubmed-article:18548087 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:18548087 | pubmed:meshHeading | pubmed-meshheading:18548087... | lld:pubmed |
| pubmed-article:18548087 | pubmed:meshHeading | pubmed-meshheading:18548087... | lld:pubmed |
| pubmed-article:18548087 | pubmed:meshHeading | pubmed-meshheading:18548087... | lld:pubmed |
| pubmed-article:18548087 | pubmed:meshHeading | pubmed-meshheading:18548087... | lld:pubmed |
| pubmed-article:18548087 | pubmed:meshHeading | pubmed-meshheading:18548087... | lld:pubmed |
| pubmed-article:18548087 | pubmed:meshHeading | pubmed-meshheading:18548087... | lld:pubmed |
| pubmed-article:18548087 | pubmed:meshHeading | pubmed-meshheading:18548087... | lld:pubmed |
| pubmed-article:18548087 | pubmed:meshHeading | pubmed-meshheading:18548087... | lld:pubmed |
| pubmed-article:18548087 | pubmed:meshHeading | pubmed-meshheading:18548087... | lld:pubmed |
| pubmed-article:18548087 | pubmed:meshHeading | pubmed-meshheading:18548087... | lld:pubmed |
| pubmed-article:18548087 | pubmed:meshHeading | pubmed-meshheading:18548087... | lld:pubmed |
| pubmed-article:18548087 | pubmed:meshHeading | pubmed-meshheading:18548087... | lld:pubmed |
| pubmed-article:18548087 | pubmed:meshHeading | pubmed-meshheading:18548087... | lld:pubmed |
| pubmed-article:18548087 | pubmed:meshHeading | pubmed-meshheading:18548087... | lld:pubmed |
| pubmed-article:18548087 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18548087 | pubmed:articleTitle | Deletion of PI3K-p85alpha gene impairs lineage commitment, terminal maturation, cytokine generation and cytotoxicity of NK cells. | lld:pubmed |
| pubmed-article:18548087 | pubmed:affiliation | Laboratory of Molecular Immunology, Blood Research Institute, Milwaukee, WI, USA. | lld:pubmed |
| pubmed-article:18548087 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18548087 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:18548087 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:18708 | entrezgene:pubmed | pubmed-article:18548087 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:18548087 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18548087 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18548087 | lld:pubmed |
