| pubmed-article:18547807 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18547807 | lifeskim:mentions | umls-concept:C0226896 | lld:lifeskim |
| pubmed-article:18547807 | lifeskim:mentions | umls-concept:C0205531 | lld:lifeskim |
| pubmed-article:18547807 | lifeskim:mentions | umls-concept:C0442027 | lld:lifeskim |
| pubmed-article:18547807 | lifeskim:mentions | umls-concept:C1527415 | lld:lifeskim |
| pubmed-article:18547807 | lifeskim:mentions | umls-concept:C0205177 | lld:lifeskim |
| pubmed-article:18547807 | lifeskim:mentions | umls-concept:C1424685 | lld:lifeskim |
| pubmed-article:18547807 | lifeskim:mentions | umls-concept:C0243076 | lld:lifeskim |
| pubmed-article:18547807 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:18547807 | lifeskim:mentions | umls-concept:C0205549 | lld:lifeskim |
| pubmed-article:18547807 | lifeskim:mentions | umls-concept:C1880355 | lld:lifeskim |
| pubmed-article:18547807 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:18547807 | pubmed:issue | 14 | lld:pubmed |
| pubmed-article:18547807 | pubmed:dateCreated | 2008-7-21 | lld:pubmed |
| pubmed-article:18547807 | pubmed:abstractText | Strategic replacement of the nitrogen of the lead compound 1 in the original cyclic urea series with a carbon resulted in the discovery of a novel, potent and orally more efficacious gamma-lactam series of selective NK(1) antagonists. Optimization of the lactam series culminated in the identification of compounds with high binding affinity and excellent oral CNS activity. | lld:pubmed |
| pubmed-article:18547807 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18547807 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18547807 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18547807 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18547807 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18547807 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18547807 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18547807 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18547807 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18547807 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:18547807 | pubmed:issn | 1464-3405 | lld:pubmed |
| pubmed-article:18547807 | pubmed:author | pubmed-author:NomeirAmin... | lld:pubmed |
| pubmed-article:18547807 | pubmed:author | pubmed-author:ReichardGrego... | lld:pubmed |
| pubmed-article:18547807 | pubmed:author | pubmed-author:WangChengC | lld:pubmed |
| pubmed-article:18547807 | pubmed:author | pubmed-author:DuffyRuth ARA | lld:pubmed |
| pubmed-article:18547807 | pubmed:author | pubmed-author:LachowiczJean... | lld:pubmed |
| pubmed-article:18547807 | pubmed:author | pubmed-author:XiaoDongD | lld:pubmed |
| pubmed-article:18547807 | pubmed:author | pubmed-author:VartyGeoffrey... | lld:pubmed |
| pubmed-article:18547807 | pubmed:author | pubmed-author:ShihNeng-Yang... | lld:pubmed |
| pubmed-article:18547807 | pubmed:author | pubmed-author:PaliwalSunilS | lld:pubmed |
| pubmed-article:18547807 | pubmed:author | pubmed-author:TsuiHon-Chung... | lld:pubmed |
| pubmed-article:18547807 | pubmed:author | pubmed-author:WrobleskiMich... | lld:pubmed |
| pubmed-article:18547807 | pubmed:author | pubmed-author:ShahSapnaS | lld:pubmed |
| pubmed-article:18547807 | pubmed:author | pubmed-author:StengoneCarmi... | lld:pubmed |
| pubmed-article:18547807 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18547807 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:18547807 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:18547807 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18547807 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18547807 | pubmed:pagination | 4168-71 | lld:pubmed |
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| pubmed-article:18547807 | pubmed:meshHeading | pubmed-meshheading:18547807... | lld:pubmed |
| pubmed-article:18547807 | pubmed:meshHeading | pubmed-meshheading:18547807... | lld:pubmed |
| pubmed-article:18547807 | pubmed:meshHeading | pubmed-meshheading:18547807... | lld:pubmed |
| pubmed-article:18547807 | pubmed:meshHeading | pubmed-meshheading:18547807... | lld:pubmed |
| pubmed-article:18547807 | pubmed:meshHeading | pubmed-meshheading:18547807... | lld:pubmed |
| pubmed-article:18547807 | pubmed:meshHeading | pubmed-meshheading:18547807... | lld:pubmed |
| pubmed-article:18547807 | pubmed:meshHeading | pubmed-meshheading:18547807... | lld:pubmed |
| pubmed-article:18547807 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18547807 | pubmed:articleTitle | Discovery of a novel, potent and orally active series of gamma-lactams as selective NK1 antagonists. | lld:pubmed |
| pubmed-article:18547807 | pubmed:affiliation | Chemical Research Department, Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. sunil.paliwal@spcorp.com | lld:pubmed |
| pubmed-article:18547807 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:18547807 | lld:chembl |
