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pubmed-article:18542235pubmed:abstractTextWe demonstrate microfluidic devices for terahertz spectroscopy of biomolecules in aqueous solutions. The devices are fabricated out of a plastic material that is both mechanically rigid and optically transparent with near-zero dispersion in the terahertz frequency range. Using a lowpower terahertz time-domain spectrometer, we experimentally measure the absorption spectra of the vibrational modes of bovine serum albumin from 0.5 - 2.5 THz and find good agreement with previously reported data obtained using large-volume solutions and a high-power free-electron laser. Our results demonstrate the feasibility of performing high sensitivity terahertz spectroscopy of biomolecules in aqueous solutions with detectable molecular quantities as small as 10 picomoles using microfluidic devices.lld:pubmed
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pubmed-article:18542235pubmed:articleTitleMicrofluidic devices for terahertz spectroscopy of biomolecules.lld:pubmed
pubmed-article:18542235pubmed:affiliationSchool of Electrical and Computer Engineering, Cornell University, Ithaca, NY, 14853, USA. pag25@cornell.edulld:pubmed
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pubmed-article:18542235pubmed:publicationTypeResearch Support, U.S. Gov't, Non-P.H.S.lld:pubmed