| pubmed-article:18533159 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18533159 | lifeskim:mentions | umls-concept:C0222661 | lld:lifeskim |
| pubmed-article:18533159 | lifeskim:mentions | umls-concept:C1801960 | lld:lifeskim |
| pubmed-article:18533159 | lifeskim:mentions | umls-concept:C0005528 | lld:lifeskim |
| pubmed-article:18533159 | lifeskim:mentions | umls-concept:C0678695 | lld:lifeskim |
| pubmed-article:18533159 | lifeskim:mentions | umls-concept:C0596578 | lld:lifeskim |
| pubmed-article:18533159 | lifeskim:mentions | umls-concept:C0080037 | lld:lifeskim |
| pubmed-article:18533159 | lifeskim:mentions | umls-concept:C2347375 | lld:lifeskim |
| pubmed-article:18533159 | lifeskim:mentions | umls-concept:C2346689 | lld:lifeskim |
| pubmed-article:18533159 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:18533159 | pubmed:dateCreated | 2008-7-15 | lld:pubmed |
| pubmed-article:18533159 | pubmed:abstractText | Load-induced fluid flow is a key factor in triggering bone modeling and remodeling processes that maintain bone mass and architecture. To provide an enhanced understanding of fluid flow in bone, unique computational models of a tibial section were developed. The purpose of the study was to examine the effects of incorporating vascular porosity on pore fluid pressure and resulting lacunocanalicular flow and to determine the role of load-induced fluid flow in tracer transport. Simulations revealed large local pressure gradients surrounding the vascular canals that were dependent on the magnitude and state (i.e., compressive or tensile) of the stress. Fluid velocity magnitudes were increased by over an order of magnitude in the dual-porosity model, relative to the single-porosity model. Fluid flow had a marked effect on tracer perfusion within the cortex. After 10 loading cycles, a 9-fold increase in tracer concentration, relative to diffusion alone, was observed in the compressive region where fluid exchange was greatest between the lacunocanalicular porosity and the vascular canals. Agreement was achieved between computational results and experimental investigations of electrokinetic phenomenon, tracer transport, cellular stimulation, and functional adaptation. The models produced substantial improvements in bone fluid flow simulation and underscored the significance of incorporating vascular porosity in models designed to quantify fluid pressure and flow characteristics within mechanically loaded cortical bone. | lld:pubmed |
| pubmed-article:18533159 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18533159 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18533159 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18533159 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18533159 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:18533159 | pubmed:issn | 0021-9290 | lld:pubmed |
| pubmed-article:18533159 | pubmed:author | pubmed-author:CooperDavidD | lld:pubmed |
| pubmed-article:18533159 | pubmed:author | pubmed-author:ZernickeRonal... | lld:pubmed |
| pubmed-article:18533159 | pubmed:author | pubmed-author:MartinuzziRob... | lld:pubmed |
| pubmed-article:18533159 | pubmed:author | pubmed-author:TranDavidD | lld:pubmed |
| pubmed-article:18533159 | pubmed:author | pubmed-author:GouletGrant... | lld:pubmed |
| pubmed-article:18533159 | pubmed:author | pubmed-author:HamiltonNicol... | lld:pubmed |
| pubmed-article:18533159 | pubmed:author | pubmed-author:CoombeDennisD | lld:pubmed |
| pubmed-article:18533159 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18533159 | pubmed:day | 19 | lld:pubmed |
| pubmed-article:18533159 | pubmed:volume | 41 | lld:pubmed |
| pubmed-article:18533159 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18533159 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18533159 | pubmed:pagination | 2169-75 | lld:pubmed |
| pubmed-article:18533159 | pubmed:dateRevised | 2009-11-11 | lld:pubmed |
| pubmed-article:18533159 | pubmed:meshHeading | pubmed-meshheading:18533159... | lld:pubmed |
| pubmed-article:18533159 | pubmed:meshHeading | pubmed-meshheading:18533159... | lld:pubmed |
| pubmed-article:18533159 | pubmed:meshHeading | pubmed-meshheading:18533159... | lld:pubmed |
| pubmed-article:18533159 | pubmed:meshHeading | pubmed-meshheading:18533159... | lld:pubmed |
| pubmed-article:18533159 | pubmed:meshHeading | pubmed-meshheading:18533159... | lld:pubmed |
| pubmed-article:18533159 | pubmed:meshHeading | pubmed-meshheading:18533159... | lld:pubmed |
| pubmed-article:18533159 | pubmed:meshHeading | pubmed-meshheading:18533159... | lld:pubmed |
| pubmed-article:18533159 | pubmed:meshHeading | pubmed-meshheading:18533159... | lld:pubmed |
| pubmed-article:18533159 | pubmed:meshHeading | pubmed-meshheading:18533159... | lld:pubmed |
| pubmed-article:18533159 | pubmed:meshHeading | pubmed-meshheading:18533159... | lld:pubmed |
| pubmed-article:18533159 | pubmed:meshHeading | pubmed-meshheading:18533159... | lld:pubmed |
| pubmed-article:18533159 | pubmed:meshHeading | pubmed-meshheading:18533159... | lld:pubmed |
| pubmed-article:18533159 | pubmed:meshHeading | pubmed-meshheading:18533159... | lld:pubmed |
| pubmed-article:18533159 | pubmed:meshHeading | pubmed-meshheading:18533159... | lld:pubmed |
| pubmed-article:18533159 | pubmed:meshHeading | pubmed-meshheading:18533159... | lld:pubmed |
| pubmed-article:18533159 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18533159 | pubmed:articleTitle | Influence of vascular porosity on fluid flow and nutrient transport in loaded cortical bone. | lld:pubmed |
| pubmed-article:18533159 | pubmed:affiliation | Schulich School of Engineering, Department of Mechanical and Manufacturing Engineering, University of Calgary, Calgary, AB, Canada. | lld:pubmed |
| pubmed-article:18533159 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18533159 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
