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| pubmed-article:18524816 | lifeskim:mentions | umls-concept:C1880389 | lld:lifeskim |
| pubmed-article:18524816 | pubmed:issue | 17 | lld:pubmed |
| pubmed-article:18524816 | pubmed:dateCreated | 2008-8-15 | lld:pubmed |
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| pubmed-article:18524816 | pubmed:abstractText | A new adeno-associated virus (AAV), referred to as AAV(VR-942), has been isolated as a contaminant of adenovirus strain simian virus 17. The sequence of the rep gene places it in the AAV serotype 2 (AAV2) complementation group, while the capsid is only 88% identical to that of AAV2. High-level AAV(VR-942) transduction activity requires cell surface heparan sulfate proteoglycans, although AAV(VR-942) lacks residues equivalent to the AAV2 R585 and R588 amino acid residues essential for mediating the interaction of AAV2 with the heparan sulfate proteoglycan receptor. Instead, AAV(VR-942) uses a distinct transduction region. This finding shows that distinct domains on different AAV isolates can be responsible for the same activities. | lld:pubmed |
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| pubmed-article:18524816 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18524816 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18524816 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:18524816 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18524816 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:18524816 | pubmed:issn | 1098-5514 | lld:pubmed |
| pubmed-article:18524816 | pubmed:author | pubmed-author:SchmidtMichae... | lld:pubmed |
| pubmed-article:18524816 | pubmed:author | pubmed-author:ChioriniJohn... | lld:pubmed |
| pubmed-article:18524816 | pubmed:author | pubmed-author:AfioneSandraS | lld:pubmed |
| pubmed-article:18524816 | pubmed:author | pubmed-author:Agbandje-McKe... | lld:pubmed |
| pubmed-article:18524816 | pubmed:author | pubmed-author:GovindasamyLa... | lld:pubmed |
| pubmed-article:18524816 | pubmed:author | pubmed-author:KaludovNickN | lld:pubmed |
| pubmed-article:18524816 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18524816 | pubmed:volume | 82 | lld:pubmed |
| pubmed-article:18524816 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18524816 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18524816 | pubmed:pagination | 8911-6 | lld:pubmed |
| pubmed-article:18524816 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:18524816 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18524816 | pubmed:articleTitle | Molecular characterization of the heparin-dependent transduction domain on the capsid of a novel adeno-associated virus isolate, AAV(VR-942). | lld:pubmed |
| pubmed-article:18524816 | pubmed:affiliation | Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA. | lld:pubmed |
| pubmed-article:18524816 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18524816 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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