| pubmed-article:18520029 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18520029 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:18520029 | lifeskim:mentions | umls-concept:C0036087 | lld:lifeskim |
| pubmed-article:18520029 | lifeskim:mentions | umls-concept:C1622418 | lld:lifeskim |
| pubmed-article:18520029 | lifeskim:mentions | umls-concept:C0081937 | lld:lifeskim |
| pubmed-article:18520029 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:18520029 | pubmed:dateCreated | 2008-6-3 | lld:pubmed |
| pubmed-article:18520029 | pubmed:abstractText | Saliva contains a large number of proteins that participate in the protection of oral tissue. We found, for the first time, small vesicles (30-130 nm in diameter) in human whole saliva. Vesicles from saliva were identified by electron microscopy after isolation by gel-filtration on Sepharose CL-4B. They resemble exosomes, which are vesicles with an endosome-derived limiting membrane that are secreted by a diverse range of cell types. We performed a biochemical characterization of these vesicles by amino acid sequence analysis and Western blot analysis. We found that they contain dipeptidyl peptidase IV (DPP IV), galectin-3 and immunoglobulin A, which have potential to influence immune response. The DPP IV in the vesicles was metabolically active in cleaving substance P and glucose-dependent insulinotropic polypeptide to release N-terminal dipeptides. Our results demonstrate that human whole saliva contains exosome-like vesicles; they might participate in the catabolism of bioactive peptides and play a regulatory role in local immune defense in the oral cavity. | lld:pubmed |
| pubmed-article:18520029 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18520029 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18520029 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18520029 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:18520029 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18520029 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18520029 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:18520029 | pubmed:issn | 0918-6158 | lld:pubmed |
| pubmed-article:18520029 | pubmed:author | pubmed-author:KawakamiHayat... | lld:pubmed |
| pubmed-article:18520029 | pubmed:author | pubmed-author:Kanai-AzumaMa... | lld:pubmed |
| pubmed-article:18520029 | pubmed:author | pubmed-author:AkimotoYoshih... | lld:pubmed |
| pubmed-article:18520029 | pubmed:author | pubmed-author:OgawaYukoY | lld:pubmed |
| pubmed-article:18520029 | pubmed:author | pubmed-author:YanoshitaRyoh... | lld:pubmed |
| pubmed-article:18520029 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18520029 | pubmed:volume | 31 | lld:pubmed |
| pubmed-article:18520029 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18520029 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18520029 | pubmed:pagination | 1059-62 | lld:pubmed |
| pubmed-article:18520029 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:18520029 | pubmed:meshHeading | pubmed-meshheading:18520029... | lld:pubmed |
| pubmed-article:18520029 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18520029 | pubmed:articleTitle | Exosome-like vesicles with dipeptidyl peptidase IV in human saliva. | lld:pubmed |
| pubmed-article:18520029 | pubmed:affiliation | Institute of Medicinal Chemistry, Hoshi University, Tokyo, Japan. | lld:pubmed |
| pubmed-article:18520029 | pubmed:publicationType | Journal Article | lld:pubmed |
| entrez-gene:1803 | entrezgene:pubmed | pubmed-article:18520029 | lld:entrezgene |
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