| pubmed-article:18519036 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18519036 | lifeskim:mentions | umls-concept:C0010798 | lld:lifeskim |
| pubmed-article:18519036 | lifeskim:mentions | umls-concept:C1999216 | lld:lifeskim |
| pubmed-article:18519036 | lifeskim:mentions | umls-concept:C0205396 | lld:lifeskim |
| pubmed-article:18519036 | lifeskim:mentions | umls-concept:C0018164 | lld:lifeskim |
| pubmed-article:18519036 | lifeskim:mentions | umls-concept:C0139705 | lld:lifeskim |
| pubmed-article:18519036 | pubmed:issue | 15 | lld:pubmed |
| pubmed-article:18519036 | pubmed:dateCreated | 2008-6-16 | lld:pubmed |
| pubmed-article:18519036 | pubmed:abstractText | Gramicidin S, a cationic cyclic decapeptide, exhibits the potent antibiotic activity through perturbation of lipid bilayers of the bacterial membrane. From the screening of natural antibiotics, we identified gramicidin S as a potent inhibitor for cytochrome bd-type quinol oxidase from Escherichia coli. We found that gramicidin S inhibited the oxidase with IC(50) of 3.5 microM by decreasing V(max) and the affinity for substrates but showed the stimulatory effect at low concentrations. Our findings would provide a new insight into the development of gramicidin S analogs, which do not share the target and mechanism with conventional antibiotics. | lld:pubmed |
| pubmed-article:18519036 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18519036 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18519036 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18519036 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18519036 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18519036 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18519036 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18519036 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18519036 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18519036 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18519036 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18519036 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18519036 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18519036 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18519036 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:18519036 | pubmed:issn | 0014-5793 | lld:pubmed |
| pubmed-article:18519036 | pubmed:author | pubmed-author:KitaKiyoshiK | lld:pubmed |
| pubmed-article:18519036 | pubmed:author | pubmed-author:OmuraSatoshiS | lld:pubmed |
| pubmed-article:18519036 | pubmed:author | pubmed-author:MogiTatsushiT | lld:pubmed |
| pubmed-article:18519036 | pubmed:author | pubmed-author:ShiomiKazuroK | lld:pubmed |
| pubmed-article:18519036 | pubmed:author | pubmed-author:UiHideakiH | lld:pubmed |
| pubmed-article:18519036 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18519036 | pubmed:day | 25 | lld:pubmed |
| pubmed-article:18519036 | pubmed:volume | 582 | lld:pubmed |
| pubmed-article:18519036 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18519036 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18519036 | pubmed:pagination | 2299-302 | lld:pubmed |
| pubmed-article:18519036 | pubmed:meshHeading | pubmed-meshheading:18519036... | lld:pubmed |
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| pubmed-article:18519036 | pubmed:meshHeading | pubmed-meshheading:18519036... | lld:pubmed |
| pubmed-article:18519036 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18519036 | pubmed:articleTitle | Gramicidin S identified as a potent inhibitor for cytochrome bd-type quinol oxidase. | lld:pubmed |
| pubmed-article:18519036 | pubmed:affiliation | Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan. tmogi@m.u-tokyo.ac.jp | lld:pubmed |
| pubmed-article:18519036 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18519036 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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