Down-regulation of toll-like receptor (TLRs) is present in animals with endotoxin tolerance. The spleen is the largest peripheral lymphatic organ in vivo, and it plays an important role in inflammatory reactivity. In this study we investigated TLR2 and TLR4 proteins in the spleen of endotoxic tolerant mice.
Department of Pathogenic Biology, School of Medicine, Suzhou University, 199 Reng-al Roud, Dushu Lake Higher Eduction Town, Suzhou, Jiangsu 215123, PR China.
