| pubmed-article:18516127 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18516127 | lifeskim:mentions | umls-concept:C0280100 | lld:lifeskim |
| pubmed-article:18516127 | lifeskim:mentions | umls-concept:C1511790 | lld:lifeskim |
| pubmed-article:18516127 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:18516127 | lifeskim:mentions | umls-concept:C0443172 | lld:lifeskim |
| pubmed-article:18516127 | pubmed:issue | 16 | lld:pubmed |
| pubmed-article:18516127 | pubmed:dateCreated | 2008-6-2 | lld:pubmed |
| pubmed-article:18516127 | pubmed:abstractText | Differentiation among malignant tumors, benign tumors, and normal tissue is highly important in the diagnosis and treatment of many malignancies. We have proposed a dynamic schema for noninvasive characterization of pressure-induced changes in solid tumors. Our hypothesis has been that the altered neovascularization processes within cancer-bearing tissues may significantly increase vascular resistance and cause a much slower response of hemoglobin concentration during a dynamic compression stimulus. This hypothesis was tested by the evaluation of data generated from human tumor clinical testing and from animal tumor model testing. In the human tumor clinical testing, a unified diagnostic criterion was derived that integrated the relative characteristics of tumor oxygen, hemoglobin, and hemoglobin dynamics. By applying such a unified criterion, we were able to differentiate benign breast lesions and malignant breast tumors with high sensitivity and specificity within a subset of 14 suspicious breast lesions with similar size and depth characteristics. In the animal testing, a stepped compression load was applied to the subcutaneous tumor deposit on an athymic NU/NU nude mouse model with subcutaneous xenograft BxPC-3 cancer. Characteristic differences were observed between the premortem tumor and the postmortem tumor in terms of pressure-induced tumor structural and functional changes. | lld:pubmed |
| pubmed-article:18516127 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18516127 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18516127 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18516127 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18516127 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18516127 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18516127 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:18516127 | pubmed:issn | 0003-6935 | lld:pubmed |
| pubmed-article:18516127 | pubmed:author | pubmed-author:WahlE FEF | lld:pubmed |
| pubmed-article:18516127 | pubmed:author | pubmed-author:PovoskiStephe... | lld:pubmed |
| pubmed-article:18516127 | pubmed:author | pubmed-author:SunDuxinD | lld:pubmed |
| pubmed-article:18516127 | pubmed:author | pubmed-author:CaoXianhuaX | lld:pubmed |
| pubmed-article:18516127 | pubmed:author | pubmed-author:XuRonald XRX | lld:pubmed |
| pubmed-article:18516127 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18516127 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:18516127 | pubmed:volume | 47 | lld:pubmed |
| pubmed-article:18516127 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18516127 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18516127 | pubmed:pagination | 3053-63 | lld:pubmed |
| pubmed-article:18516127 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:18516127 | pubmed:meshHeading | pubmed-meshheading:18516127... | lld:pubmed |
| pubmed-article:18516127 | pubmed:meshHeading | pubmed-meshheading:18516127... | lld:pubmed |
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| pubmed-article:18516127 | pubmed:meshHeading | pubmed-meshheading:18516127... | lld:pubmed |
| pubmed-article:18516127 | pubmed:meshHeading | pubmed-meshheading:18516127... | lld:pubmed |
| pubmed-article:18516127 | pubmed:meshHeading | pubmed-meshheading:18516127... | lld:pubmed |
| pubmed-article:18516127 | pubmed:meshHeading | pubmed-meshheading:18516127... | lld:pubmed |
| pubmed-article:18516127 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18516127 | pubmed:articleTitle | Dynamic schema for near infrared detection of pressure-induced changes in solid tumors. | lld:pubmed |
| pubmed-article:18516127 | pubmed:affiliation | Department of Biomedical Engineering, Ohio State University, Columbus, OH 43210, USA. | lld:pubmed |
| pubmed-article:18516127 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18516127 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18516127 | lld:pubmed |
