| pubmed-article:18515970 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18515970 | lifeskim:mentions | umls-concept:C0005821 | lld:lifeskim |
| pubmed-article:18515970 | lifeskim:mentions | umls-concept:C0016011 | lld:lifeskim |
| pubmed-article:18515970 | lifeskim:mentions | umls-concept:C0003241 | lld:lifeskim |
| pubmed-article:18515970 | lifeskim:mentions | umls-concept:C0175631 | lld:lifeskim |
| pubmed-article:18515970 | lifeskim:mentions | umls-concept:C2827662 | lld:lifeskim |
| pubmed-article:18515970 | lifeskim:mentions | umls-concept:C0024485 | lld:lifeskim |
| pubmed-article:18515970 | lifeskim:mentions | umls-concept:C0599894 | lld:lifeskim |
| pubmed-article:18515970 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:18515970 | lifeskim:mentions | umls-concept:C1521840 | lld:lifeskim |
| pubmed-article:18515970 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:18515970 | pubmed:dateCreated | 2008-12-9 | lld:pubmed |
| pubmed-article:18515970 | pubmed:abstractText | Ruptured atherosclerotic plaques, lined with activated platelets, constitute an attractive target for magnetic resonance imaging (MRI). This study evaluated whether microparticles of iron oxide (MPIO) targeting ligand-induced binding sites (LIBS) on the activated conformation of glycoprotein IIb/IIIa could be used to image platelets. MPIO (size: 1 microm) were conjugated to anti-LIBS or control single-chain antibody. Following guidewire injury to mouse femoral artery, platelet adhesion was present after 24 h. Mice were perfused with anti-LIBS-MPIO (or control MPIO) via the left ventricle and 11.7-tesla MRI was performed on femoral arteries ex vivo. A 3D gradient echo sequence attained an isotropic resolution of 25 microm. MPIO binding, quantified by MRI, was 4-fold higher with anti-LIBS-MPIO in comparison to control MPIO (p < 0.01). In histological sections, low signal zones on MRI and MPIO correlated strongly (R(2) = 0.72; p < 0.001), indicating accurate MR quantification. In conclusion, anti-LIBS-MPIO bind to activated platelets in mouse arteries, providing a basis for the use of function-specific single-chain antibody-MPIO conjugates for molecular MRI, and represent the first molecular imaging of a conformational change in a surface receptor. This presents an opportunity to specifically image activated platelets involved in acute atherothrombosis with MRI. | lld:pubmed |
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| pubmed-article:18515970 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18515970 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18515970 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:18515970 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18515970 | pubmed:issn | 1423-0135 | lld:pubmed |
| pubmed-article:18515970 | pubmed:author | pubmed-author:ChannonKeith... | lld:pubmed |
| pubmed-article:18515970 | pubmed:author | pubmed-author:BodeChristoph... | lld:pubmed |
| pubmed-article:18515970 | pubmed:author | pubmed-author:PeterKarlhein... | lld:pubmed |
| pubmed-article:18515970 | pubmed:author | pubmed-author:AliZiad AZA | lld:pubmed |
| pubmed-article:18515970 | pubmed:author | pubmed-author:NeubauerStefa... | lld:pubmed |
| pubmed-article:18515970 | pubmed:author | pubmed-author:ChoudhuryRobi... | lld:pubmed |
| pubmed-article:18515970 | pubmed:author | pubmed-author:McAteerMartin... | lld:pubmed |
| pubmed-article:18515970 | pubmed:author | pubmed-author:SchneiderJurg... | lld:pubmed |
| pubmed-article:18515970 | pubmed:author | pubmed-author:von zur... | lld:pubmed |
| pubmed-article:18515970 | pubmed:copyrightInfo | Copyright 2008 S. Karger AG, Basel. | lld:pubmed |
| pubmed-article:18515970 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18515970 | pubmed:volume | 46 | lld:pubmed |
| pubmed-article:18515970 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18515970 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18515970 | pubmed:pagination | 6-14 | lld:pubmed |
| pubmed-article:18515970 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:18515970 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:18515970 | pubmed:articleTitle | Visualization of activated platelets by targeted magnetic resonance imaging utilizing conformation-specific antibodies against glycoprotein IIb/IIIa. | lld:pubmed |
| pubmed-article:18515970 | pubmed:affiliation | Department of Cardiovascular Medicine, University of Oxford, Oxford, UK. | lld:pubmed |
| pubmed-article:18515970 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18515970 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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