| pubmed-article:18509034 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18509034 | lifeskim:mentions | umls-concept:C1422223 | lld:lifeskim |
| pubmed-article:18509034 | lifeskim:mentions | umls-concept:C0004461 | lld:lifeskim |
| pubmed-article:18509034 | lifeskim:mentions | umls-concept:C1523840 | lld:lifeskim |
| pubmed-article:18509034 | lifeskim:mentions | umls-concept:C1704332 | lld:lifeskim |
| pubmed-article:18509034 | lifeskim:mentions | umls-concept:C0439799 | lld:lifeskim |
| pubmed-article:18509034 | pubmed:issue | 22 | lld:pubmed |
| pubmed-article:18509034 | pubmed:dateCreated | 2008-5-29 | lld:pubmed |
| pubmed-article:18509034 | pubmed:abstractText | Postsynaptic density-93 (PSD-93)/Chapsyn-110 is a PDZ (PSD-95/Discs large/zona occludens-1) domain-containing membrane-associated guanylate kinase (MAGUK) that functions as a scaffold to assemble channels, receptors, and other signaling proteins at cell membranes. PSD-93 is highly enriched at synapses, but mice lacking this protein have no synaptic structural abnormalities, probably because of overlapping expression and redundancy with other MAGUKs. Consequently, the function of PSD-93 is not well understood. Here, we show that PSD-93, but not other MAGUKs, is enriched at the axon initial segment (AIS), where it colocalizes with Kv1.1, Kv1.2, Kv1.4, and Kvbeta2 subunit-containing K(+) channels, Caspr2, and TAG-1 (transient axonal glycoprotein-1). When coexpressed with Kv1 channels in heterologous cells, PSD-93 induces formation of large cell-surface clusters. Knockdown of PSD-93 in cultured hippocampal neurons by RNA interference disrupted Kv1 channel localization at the AIS. Similarly, PSD-93-/- mice failed to cluster Kv1 channels at the AIS of cortical and hippocampal neurons. In contrast, Caspr2, which mediates Kv1 channel clustering at the juxtaparanode, is not required for localization of Kv1 channels at the AIS. These results show PSD-93 mediates AIS accumulation of Kv1 channels independently of Caspr2. | lld:pubmed |
| pubmed-article:18509034 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18509034 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18509034 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18509034 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18509034 | pubmed:month | May | lld:pubmed |
| pubmed-article:18509034 | pubmed:issn | 1529-2401 | lld:pubmed |
| pubmed-article:18509034 | pubmed:author | pubmed-author:OgawaYasuhiro... | lld:pubmed |
| pubmed-article:18509034 | pubmed:author | pubmed-author:TrimmerJames... | lld:pubmed |
| pubmed-article:18509034 | pubmed:author | pubmed-author:PelesEliorE | lld:pubmed |
| pubmed-article:18509034 | pubmed:author | pubmed-author:BredtDavid... | lld:pubmed |
| pubmed-article:18509034 | pubmed:author | pubmed-author:RasbandMatthe... | lld:pubmed |
| pubmed-article:18509034 | pubmed:author | pubmed-author:HorreshIdoI | lld:pubmed |
| pubmed-article:18509034 | pubmed:issnType | Electronic | lld:pubmed |
