| pubmed-article:18508765 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18508765 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:18508765 | lifeskim:mentions | umls-concept:C0018801 | lld:lifeskim |
| pubmed-article:18508765 | lifeskim:mentions | umls-concept:C0018787 | lld:lifeskim |
| pubmed-article:18508765 | lifeskim:mentions | umls-concept:C0597298 | lld:lifeskim |
| pubmed-article:18508765 | lifeskim:mentions | umls-concept:C1539079 | lld:lifeskim |
| pubmed-article:18508765 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:18508765 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:18508765 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:18508765 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:18508765 | pubmed:issue | 32 | lld:pubmed |
| pubmed-article:18508765 | pubmed:dateCreated | 2008-8-4 | lld:pubmed |
| pubmed-article:18508765 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18508765 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18508765 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18508765 | pubmed:abstractText | Myocardial infarction (MI) is often followed by heart failure (HF), but the mechanisms precipitating the transition to HF remain largely unknown. A genomic profile was performed in a monkey model of MI, from the myocardium adjacent to chronic (2-month) MI followed by 3 weeks of pacing to develop HF. The transcript of the gene encoding the cell cycle-related kinase (CCRK) was down-regulated by 50% in HF heart compared with control (p<0.05), which was confirmed by quantitative PCR. The CCRK sequence cloned from a heart library showed a conservation of the N-terminal kinase domain when compared with the "generic" isoform cloned previously but a different C-terminal half due to alternative splicing with frameshift. The homology of the cardiac sequence was 100% between mice and humans. Expression of the corresponding protein, measured upon generation of a monoclonal antibody, was limited to heart, liver, and kidney. Upon overexpression in cardiac myocytes, both isoforms promote cell growth and reduce apoptosis by chelerythrine (p<0.05 versus control). Using a yeast two-hybrid screening, we found an interaction of the generic but not the cardiac CCRK with cyclin H and casein kinase 2. In addition, only the generic CCRK phosphorylates the cyclin-dependent kinase 2, which was accompanied by a doubling of myocytes in the S and G(2) phases of the cell cycle (p < 0.05 versus control). Therefore, the heart expresses a splice variant of CCRK, which promotes cardiac cell growth and survival; differs from the generic isoform in terms of protein-protein interactions, substrate specificity and regulation of the cell cycle; and is down-regulated significantly in HF. | lld:pubmed |
| pubmed-article:18508765 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18508765 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18508765 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18508765 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18508765 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18508765 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18508765 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18508765 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18508765 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18508765 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18508765 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18508765 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18508765 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18508765 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18508765 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18508765 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18508765 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18508765 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18508765 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18508765 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18508765 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18508765 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18508765 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18508765 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18508765 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18508765 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18508765 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18508765 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18508765 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18508765 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18508765 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18508765 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18508765 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18508765 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18508765 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18508765 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18508765 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18508765 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18508765 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18508765 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18508765 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18508765 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18508765 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18508765 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18508765 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18508765 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18508765 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:18508765 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:18508765 | pubmed:author | pubmed-author:RauhGG | lld:pubmed |
| pubmed-article:18508765 | pubmed:author | pubmed-author:VatnerStephen... | lld:pubmed |
| pubmed-article:18508765 | pubmed:author | pubmed-author:VatnerDorothy... | lld:pubmed |
| pubmed-article:18508765 | pubmed:author | pubmed-author:HongChullC | lld:pubmed |
| pubmed-article:18508765 | pubmed:author | pubmed-author:DepreChristop... | lld:pubmed |
| pubmed-article:18508765 | pubmed:author | pubmed-author:QiuHongyuH | lld:pubmed |
| pubmed-article:18508765 | pubmed:author | pubmed-author:PainJayashree... | lld:pubmed |
| pubmed-article:18508765 | pubmed:author | pubmed-author:ShahRinaR | lld:pubmed |
| pubmed-article:18508765 | pubmed:author | pubmed-author:DaiHuachengH | lld:pubmed |
| pubmed-article:18508765 | pubmed:author | pubmed-author:JainKomalK | lld:pubmed |
| pubmed-article:18508765 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18508765 | pubmed:day | 8 | lld:pubmed |
| pubmed-article:18508765 | pubmed:volume | 283 | lld:pubmed |
| pubmed-article:18508765 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18508765 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18508765 | pubmed:pagination | 22157-65 | lld:pubmed |
| pubmed-article:18508765 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:18508765 | pubmed:meshHeading | pubmed-meshheading:18508765... | lld:pubmed |
| pubmed-article:18508765 | pubmed:meshHeading | pubmed-meshheading:18508765... | lld:pubmed |
| pubmed-article:18508765 | pubmed:meshHeading | pubmed-meshheading:18508765... | lld:pubmed |
| pubmed-article:18508765 | pubmed:meshHeading | pubmed-meshheading:18508765... | lld:pubmed |
| pubmed-article:18508765 | pubmed:meshHeading | pubmed-meshheading:18508765... | lld:pubmed |
| pubmed-article:18508765 | pubmed:meshHeading | pubmed-meshheading:18508765... | lld:pubmed |
| pubmed-article:18508765 | pubmed:meshHeading | pubmed-meshheading:18508765... | lld:pubmed |
| pubmed-article:18508765 | pubmed:meshHeading | pubmed-meshheading:18508765... | lld:pubmed |
| pubmed-article:18508765 | pubmed:meshHeading | pubmed-meshheading:18508765... | lld:pubmed |
| pubmed-article:18508765 | pubmed:meshHeading | pubmed-meshheading:18508765... | lld:pubmed |
| pubmed-article:18508765 | pubmed:meshHeading | pubmed-meshheading:18508765... | lld:pubmed |
| pubmed-article:18508765 | pubmed:meshHeading | pubmed-meshheading:18508765... | lld:pubmed |
| pubmed-article:18508765 | pubmed:meshHeading | pubmed-meshheading:18508765... | lld:pubmed |
| pubmed-article:18508765 | pubmed:meshHeading | pubmed-meshheading:18508765... | lld:pubmed |
| pubmed-article:18508765 | pubmed:meshHeading | pubmed-meshheading:18508765... | lld:pubmed |
| pubmed-article:18508765 | pubmed:meshHeading | pubmed-meshheading:18508765... | lld:pubmed |
| pubmed-article:18508765 | pubmed:meshHeading | pubmed-meshheading:18508765... | lld:pubmed |
| pubmed-article:18508765 | pubmed:meshHeading | pubmed-meshheading:18508765... | lld:pubmed |
| pubmed-article:18508765 | pubmed:meshHeading | pubmed-meshheading:18508765... | lld:pubmed |
