| pubmed-article:18508264 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18508264 | lifeskim:mentions | umls-concept:C0030020 | lld:lifeskim |
| pubmed-article:18508264 | lifeskim:mentions | umls-concept:C0033681 | lld:lifeskim |
| pubmed-article:18508264 | lifeskim:mentions | umls-concept:C1414313 | lld:lifeskim |
| pubmed-article:18508264 | lifeskim:mentions | umls-concept:C0243077 | lld:lifeskim |
| pubmed-article:18508264 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:18508264 | lifeskim:mentions | umls-concept:C1554184 | lld:lifeskim |
| pubmed-article:18508264 | lifeskim:mentions | umls-concept:C1880355 | lld:lifeskim |
| pubmed-article:18508264 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:18508264 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:18508264 | pubmed:dateCreated | 2008-6-10 | lld:pubmed |
| pubmed-article:18508264 | pubmed:abstractText | We herein disclose a novel series of 4-aminopyrimidine-5-carbaldehyde oximes that are potent and selective inhibitors of both EGFR and ErbB-2 tyrosine kinases, with IC(50) values in the nanomolar range. Structure-activity relationship (SAR) studies elucidated a critical role for the 4-amino and C-6 arylamino moieties. The X-ray co-crystal structure of EGFR with 37 was determined and validated our design rationale. | lld:pubmed |
| pubmed-article:18508264 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18508264 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18508264 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18508264 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18508264 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18508264 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18508264 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18508264 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18508264 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18508264 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18508264 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:18508264 | pubmed:issn | 1464-3405 | lld:pubmed |
| pubmed-article:18508264 | pubmed:author | pubmed-author:AdamsMaryM | lld:pubmed |
| pubmed-article:18508264 | pubmed:author | pubmed-author:XuGuozhangG | lld:pubmed |
| pubmed-article:18508264 | pubmed:author | pubmed-author:AbadMarta CMC | lld:pubmed |
| pubmed-article:18508264 | pubmed:author | pubmed-author:GreenbergerLe... | lld:pubmed |
| pubmed-article:18508264 | pubmed:author | pubmed-author:ConnollyPeter... | lld:pubmed |
| pubmed-article:18508264 | pubmed:author | pubmed-author:MiddletonStev... | lld:pubmed |
| pubmed-article:18508264 | pubmed:author | pubmed-author:HughesTerry... | lld:pubmed |
| pubmed-article:18508264 | pubmed:author | pubmed-author:GruningerRobe... | lld:pubmed |
| pubmed-article:18508264 | pubmed:author | pubmed-author:SpringerBarry... | lld:pubmed |
| pubmed-article:18508264 | pubmed:author | pubmed-author:EmanuelStuart... | lld:pubmed |
| pubmed-article:18508264 | pubmed:author | pubmed-author:Fuentes-Pesqu... | lld:pubmed |
| pubmed-article:18508264 | pubmed:author | pubmed-author:PandeyNiranja... | lld:pubmed |
| pubmed-article:18508264 | pubmed:author | pubmed-author:Moreno-MazzaS... | lld:pubmed |
| pubmed-article:18508264 | pubmed:author | pubmed-author:StrubleGeoffr... | lld:pubmed |
| pubmed-article:18508264 | pubmed:author | pubmed-author:NeeperMichael... | lld:pubmed |
| pubmed-article:18508264 | pubmed:author | pubmed-author:BeckAmanda... | lld:pubmed |
| pubmed-article:18508264 | pubmed:author | pubmed-author:SearleLily... | lld:pubmed |
| pubmed-article:18508264 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18508264 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:18508264 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:18508264 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18508264 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18508264 | pubmed:pagination | 3495-9 | lld:pubmed |
| pubmed-article:18508264 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:18508264 | pubmed:meshHeading | pubmed-meshheading:18508264... | lld:pubmed |
| pubmed-article:18508264 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18508264 | pubmed:articleTitle | Discovery of novel 4-amino-6-arylaminopyrimidine-5-carbaldehyde oximes as dual inhibitors of EGFR and ErbB-2 protein tyrosine kinases. | lld:pubmed |
| pubmed-article:18508264 | pubmed:affiliation | Johnson & Johnson Pharmaceutical Research & Development, Medicinal Chemistry, 8 Clarke Drive, Cranbury, NJ 08512, USA. gxu4@prdus.jnj.com | lld:pubmed |
| pubmed-article:18508264 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18508264 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:18508264 | lld:chembl |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18508264 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18508264 | lld:pubmed |
