| pubmed-article:18506882 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18506882 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:18506882 | lifeskim:mentions | umls-concept:C0022646 | lld:lifeskim |
| pubmed-article:18506882 | lifeskim:mentions | umls-concept:C0027697 | lld:lifeskim |
| pubmed-article:18506882 | lifeskim:mentions | umls-concept:C0013126 | lld:lifeskim |
| pubmed-article:18506882 | lifeskim:mentions | umls-concept:C1415900 | lld:lifeskim |
| pubmed-article:18506882 | lifeskim:mentions | umls-concept:C0205373 | lld:lifeskim |
| pubmed-article:18506882 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:18506882 | pubmed:dateCreated | 2008-7-1 | lld:pubmed |
| pubmed-article:18506882 | pubmed:abstractText | The impact of IFN-alpha secretion on disease progression was assessed by comparing phenotypic changes in the lupus-prone B6.Sle1Sle2Sle3 (B6.Sle123) strain and the parental C57BL/6 (B6) congenic partner using an adenovirus (ADV) expression vector containing a recombinant IFN-alpha gene cassette (IFN-ADV). A comprehensive comparison of cell lineage composition and activation in young B6 and B6.Sle123 mice revealed a variety of cellular alterations in the presence and absence of systemic IFN-alpha. Most IFN-alpha-induced phenotypes were similar in B6 and B6.Sle123 mice; however, B6.Sle123 mice uniquely exhibited increased B1 and plasma cells after IFN-alpha exposure, although both strains had an overall loss of mature B cells in the bone marrow, spleen and periphery. Although most of the cellular effects of IFN-alpha were identical in both strains, severe glomerulonephritis occurred only in B6.Sle123 mice. Mice injected with IFN-ADV showed an increase in immune complex deposition in the kidney, together with an unexpected decrease in serum anti-nuclear antibody levels. In summary, the predominant impact of systemic IFN-alpha in this murine model is an exacerbation of mechanisms mediating end organ damage. | lld:pubmed |
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| pubmed-article:18506882 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:18506882 | pubmed:citationSubset | IM | lld:pubmed |
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