| pubmed-article:18506848 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18506848 | lifeskim:mentions | umls-concept:C1420331 | lld:lifeskim |
| pubmed-article:18506848 | lifeskim:mentions | umls-concept:C0262950 | lld:lifeskim |
| pubmed-article:18506848 | lifeskim:mentions | umls-concept:C0205107 | lld:lifeskim |
| pubmed-article:18506848 | lifeskim:mentions | umls-concept:C0040648 | lld:lifeskim |
| pubmed-article:18506848 | lifeskim:mentions | umls-concept:C0086860 | lld:lifeskim |
| pubmed-article:18506848 | lifeskim:mentions | umls-concept:C0598067 | lld:lifeskim |
| pubmed-article:18506848 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:18506848 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:18506848 | lifeskim:mentions | umls-concept:C0279266 | lld:lifeskim |
| pubmed-article:18506848 | lifeskim:mentions | umls-concept:C0179400 | lld:lifeskim |
| pubmed-article:18506848 | lifeskim:mentions | umls-concept:C1554080 | lld:lifeskim |
| pubmed-article:18506848 | lifeskim:mentions | umls-concept:C1706198 | lld:lifeskim |
| pubmed-article:18506848 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:18506848 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:18506848 | pubmed:dateCreated | 2008-7-29 | lld:pubmed |
| pubmed-article:18506848 | pubmed:abstractText | Mouse embryonic fibroblasts (MEFs) can be differentiated into fully functional chondrocytes in response to bone morphogenetic protein-2 (BMP-2). The expression of Sox9, a critical transcription factor for the multiple steps of chondrogenesis, has been reported to be upregulated during this process. But the molecular mechanisms by which BMP-2 promotes chondrogenesis still remain largely unknown. The aim of the present study was therefore to investigate the underlying mechanism. In the MEFs, BMP-2 efficiently induced Sox9 expression along with chondrogenic differentiation in a time- and dose-dependent manner. SB203580, a specific inhibitor for p38 pathway, blocked BMP-2-induced chondrogenic differentiation as well as Sox9 expression and its transactivation of downstream genes. Forced expression of Smad6, a natural antagonist for BMP/Smad pathway, only inhibited Sox9 protein function without rendering any effects on its mRNA expression. A CCAAT box was identified in Sox9 promoter as the cis-elements responsible for BMP-2 stimulation. This study provides insight into the mechanisms underlying BMP-2-regulated Sox9 expression and activity in MEFs, and suggests differential roles of BMP-2/p38 and BMP-2/Smad pathways in modulating the function of Sox9 during chondrogenesis. | lld:pubmed |
| pubmed-article:18506848 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18506848 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18506848 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:18506848 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18506848 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:18506848 | pubmed:issn | 1097-4652 | lld:pubmed |
| pubmed-article:18506848 | pubmed:author | pubmed-author:PyeS DSD | lld:pubmed |
| pubmed-article:18506848 | pubmed:author | pubmed-author:WuHongH | lld:pubmed |
| pubmed-article:18506848 | pubmed:author | pubmed-author:LiChunshengC | lld:pubmed |
| pubmed-article:18506848 | pubmed:author | pubmed-author:WanYangY | lld:pubmed |
| pubmed-article:18506848 | pubmed:author | pubmed-author:SunFenyongF | lld:pubmed |
| pubmed-article:18506848 | pubmed:author | pubmed-author:ChenQiongyuQ | lld:pubmed |
| pubmed-article:18506848 | pubmed:author | pubmed-author:PanQiuhuiQ | lld:pubmed |
| pubmed-article:18506848 | pubmed:author | pubmed-author:YuYongchunY | lld:pubmed |
| pubmed-article:18506848 | pubmed:copyrightInfo | (c) 2008 Wiley-Liss, Inc. | lld:pubmed |
| pubmed-article:18506848 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18506848 | pubmed:volume | 217 | lld:pubmed |
| pubmed-article:18506848 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18506848 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18506848 | pubmed:pagination | 228-41 | lld:pubmed |
| pubmed-article:18506848 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:18506848 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18506848 | pubmed:articleTitle | Sox9, a key transcription factor of bone morphogenetic protein-2-induced chondrogenesis, is activated through BMP pathway and a CCAAT box in the proximal promoter. | lld:pubmed |
| pubmed-article:18506848 | pubmed:affiliation | Medical Research Center, the Second Affiliated Hospital, Sun Yat-sen University, Guangzhou City, Guangdong Province, PR China. | lld:pubmed |
| pubmed-article:18506848 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18506848 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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