| pubmed-article:18505851 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18505851 | lifeskim:mentions | umls-concept:C0021311 | lld:lifeskim |
| pubmed-article:18505851 | lifeskim:mentions | umls-concept:C0015576 | lld:lifeskim |
| pubmed-article:18505851 | lifeskim:mentions | umls-concept:C0014507 | lld:lifeskim |
| pubmed-article:18505851 | lifeskim:mentions | umls-concept:C0014834 | lld:lifeskim |
| pubmed-article:18505851 | lifeskim:mentions | umls-concept:C0001699 | lld:lifeskim |
| pubmed-article:18505851 | lifeskim:mentions | umls-concept:C0018684 | lld:lifeskim |
| pubmed-article:18505851 | lifeskim:mentions | umls-concept:C1521991 | lld:lifeskim |
| pubmed-article:18505851 | lifeskim:mentions | umls-concept:C0370215 | lld:lifeskim |
| pubmed-article:18505851 | lifeskim:mentions | umls-concept:C0039725 | lld:lifeskim |
| pubmed-article:18505851 | lifeskim:mentions | umls-concept:C0243130 | lld:lifeskim |
| pubmed-article:18505851 | lifeskim:mentions | umls-concept:C0678227 | lld:lifeskim |
| pubmed-article:18505851 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:18505851 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:18505851 | pubmed:dateCreated | 2008-7-28 | lld:pubmed |
| pubmed-article:18505851 | pubmed:abstractText | Extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae have rapidly spread worldwide and pose a serious threat for health care-associated (HA) infection. We conducted molecular detection and characterization of ESBL-related bla genes, including bla(TEM), bla(SHV), bla(CTX-M), bla(VEB), bla(OXA), bla(PER), and bla(GES), among 362 isolates of ESBL-producing E. coli (n = 235) and ESBL-producing K. pneumoniae (n = 127) collected from patients who met the definition of HA infection at two major university hospitals in Thailand from December 2004 to May 2005. The prevalence of ESBL-producing E. coli and ESBL-producing K. pneumoniae, patient demographics and the susceptibilities of these bacteria to various antimicrobial agents were described. A total of 87.3% of isolates carried several bla genes. The prevalence of bla(CTX-M) was strikingly high: 99.6% for ESBL-producing E. coli (CTX-M-14, -15, -27, -40, and -55) and 99.2% for ESBL-producing K. pneumoniae (CTX-M-3, -14, -15, -27, and -55). ISEcp1 was found in the upstream region of bla(CTX-M) in most isolates. Up to 77.0% and 71.7% of ESBL-producing E. coli and ESBL-producing K. pneumoniae, respectively, carried bla(TEM); all of them encoded TEM-1. ESBL-producing K. pneumoniae carried bla(SHV) at 87.4% (SHV-1, -2a, -11, -12, -27, -71, and -75) but only at 3.8% for ESBL-producing E. coli (SHV-11 and -12). bla genes encoding VEB-1 and OXA-10 were found in both ESBL-producing E. coli (8.5% and 8.1%, respectively) and ESBL-producing K. pneumoniae (10.2% and 11.8%, respectively). None of the isolates were positive for bla(PER) and bla(GES). Pulsed-field gel electrophoresis analysis demonstrated that there was no major clonal relationship among these ESBL producers. This is the first study to report CTX-M-3, CTX-M-27, CTX-M-40, SHV-27, SHV-71, and SHV-75 in Thailand and to show that CTX-M ESBL is highly endemic in the country. | lld:pubmed |
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| pubmed-article:18505851 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18505851 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18505851 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:18505851 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18505851 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:18505851 | pubmed:issn | 1098-6596 | lld:pubmed |
| pubmed-article:18505851 | pubmed:author | pubmed-author:Apisarnthanar... | lld:pubmed |
| pubmed-article:18505851 | pubmed:author | pubmed-author:KiratisinPatt... | lld:pubmed |
| pubmed-article:18505851 | pubmed:author | pubmed-author:SaifonPiyawan... | lld:pubmed |
| pubmed-article:18505851 | pubmed:author | pubmed-author:LaesripaChait... | lld:pubmed |
| pubmed-article:18505851 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18505851 | pubmed:volume | 52 | lld:pubmed |
| pubmed-article:18505851 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18505851 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18505851 | pubmed:pagination | 2818-24 | lld:pubmed |
| pubmed-article:18505851 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:18505851 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18505851 | pubmed:articleTitle | Molecular characterization and epidemiology of extended-spectrum-beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae isolates causing health care-associated infection in Thailand, where the CTX-M family is endemic. | lld:pubmed |
| pubmed-article:18505851 | pubmed:affiliation | Department of Microbiology, Faculty of Medicine, Siriraj Hospital, Mahidol University, 2 Prannok Rd., Bangkok-Noi, Bangkok 10700, Thailand. sipkr@mahidol.ac.th | lld:pubmed |
| pubmed-article:18505851 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18505851 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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