| pubmed-article:18505820 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18505820 | lifeskim:mentions | umls-concept:C0254610 | lld:lifeskim |
| pubmed-article:18505820 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:18505820 | lifeskim:mentions | umls-concept:C0079189 | lld:lifeskim |
| pubmed-article:18505820 | lifeskim:mentions | umls-concept:C0300804 | lld:lifeskim |
| pubmed-article:18505820 | lifeskim:mentions | umls-concept:C2003941 | lld:lifeskim |
| pubmed-article:18505820 | lifeskim:mentions | umls-concept:C1159342 | lld:lifeskim |
| pubmed-article:18505820 | pubmed:issue | 15 | lld:pubmed |
| pubmed-article:18505820 | pubmed:dateCreated | 2008-7-17 | lld:pubmed |
| pubmed-article:18505820 | pubmed:abstractText | While it is well appreciated that receptors for secreted cytokines transmit ligand-induced signals, little is known about additional roles for cytokine receptor components in the control of ligand transport and secretion. Here, we show that interleukin-15 (IL-15) translocation into the endoplasmic reticulum occurs independently of the presence of IL-15 receptor alpha (IL-15R alpha). Subsequently, however, IL-15 is transported through the Golgi apparatus only in association with IL-15R alpha and then is secreted. This intracellular IL-15/IL-15R alpha complex already is formed in the endoplasmic reticulum and, thus, enables the further trafficking of complexed IL-15 through the secretory pathway. Just transfecting IL-15R alpha in cells, which transcribe but normally do not secrete IL-15, suffices to induce IL-15 secretion. Thus, we provide the first evidence of how a cytokine is chaperoned through the secretory pathway by complexing with its own high-affinity receptor and show that IL-15/IL-15R alpha offers an excellent model system for the further exploration of this novel mechanism for the control of cytokine secretion. | lld:pubmed |
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| pubmed-article:18505820 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18505820 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18505820 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18505820 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:18505820 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18505820 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:18505820 | pubmed:issn | 1098-5549 | lld:pubmed |
| pubmed-article:18505820 | pubmed:author | pubmed-author:PausRalfR | lld:pubmed |
| pubmed-article:18505820 | pubmed:author | pubmed-author:Bulfone-PausS... | lld:pubmed |
| pubmed-article:18505820 | pubmed:author | pubmed-author:OrinskaZaneZ | lld:pubmed |
| pubmed-article:18505820 | pubmed:author | pubmed-author:BulanovaElena... | lld:pubmed |
| pubmed-article:18505820 | pubmed:author | pubmed-author:DuitmanErwin... | lld:pubmed |
| pubmed-article:18505820 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18505820 | pubmed:volume | 28 | lld:pubmed |
| pubmed-article:18505820 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18505820 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18505820 | pubmed:pagination | 4851-61 | lld:pubmed |
| pubmed-article:18505820 | pubmed:dateRevised | 2010-4-27 | lld:pubmed |
| pubmed-article:18505820 | pubmed:meshHeading | pubmed-meshheading:18505820... | lld:pubmed |
