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pubmed-article:18504411pubmed:dateCreated2008-5-27lld:pubmed
pubmed-article:18504411pubmed:abstractTextChurg-Strauss syndrome (CSS) is a rare systemic necrotizing vasculitis that develops in some asthma patients. However, it remains unknown what types of asthma patients can develop this condition. In addition, CSS patients experience eosinophilic pneumonia (EP) before the onset, but some asthma patients do not develop CSS following EP. Few studies have addressed the immunological differences in both cases. Additionally, it is well known that abnormality or failure of immunological tolerance by regulatory T cells (Treg) directly triggers the onset of autoimmune diseases. To elucidate the involvement of Treg in the difference in the pathogenesis of patients with and without CSS, the frequency of naturally occurring Treg (nTreg) and Treg which dominantly produce IL-10 and TGF-beta (Tr1) was measured in peripheral blood.lld:pubmed
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pubmed-article:18504411pubmed:statusMEDLINElld:pubmed
pubmed-article:18504411pubmed:issn1423-0097lld:pubmed
pubmed-article:18504411pubmed:authorpubmed-author:SaitoHiroshiHlld:pubmed
pubmed-article:18504411pubmed:authorpubmed-author:TsuburaiTakah...lld:pubmed
pubmed-article:18504411pubmed:authorpubmed-author:AkiyamaKazuoKlld:pubmed
pubmed-article:18504411pubmed:authorpubmed-author:TsurikisawaNa...lld:pubmed
pubmed-article:18504411pubmed:copyrightInfoCopyright 2008 S. Karger AG, Basel.lld:pubmed
pubmed-article:18504411pubmed:issnTypeElectroniclld:pubmed
pubmed-article:18504411pubmed:volume146 Suppl 1lld:pubmed
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pubmed-article:18504411pubmed:year2008lld:pubmed
pubmed-article:18504411pubmed:articleTitleInvolvement of regulatory T cells in the pathogenesis of Churg-Strauss syndrome.lld:pubmed
pubmed-article:18504411pubmed:affiliationClinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara Hospital, Sagamihara, Japan.lld:pubmed
pubmed-article:18504411pubmed:publicationTypeJournal Articlelld:pubmed