| pubmed-article:18502795 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18502795 | lifeskim:mentions | umls-concept:C0034085 | lld:lifeskim |
| pubmed-article:18502795 | lifeskim:mentions | umls-concept:C0441635 | lld:lifeskim |
| pubmed-article:18502795 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:18502795 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:18502795 | lifeskim:mentions | umls-concept:C1442758 | lld:lifeskim |
| pubmed-article:18502795 | lifeskim:mentions | umls-concept:C0598435 | lld:lifeskim |
| pubmed-article:18502795 | lifeskim:mentions | umls-concept:C0871161 | lld:lifeskim |
| pubmed-article:18502795 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:18502795 | pubmed:dateCreated | 2008-8-18 | lld:pubmed |
| pubmed-article:18502795 | pubmed:abstractText | It has been proposed that palmitoylation of the N-terminal segment of surfactant protein SP-C is important for maintaining association of pulmonary surfactant complexes with interfacial films compressed to high pressures at the end of expiration. In this study, we examined surfactant membrane models containing palmitoylated and nonpalmitoylated synthetic peptides, based on the N-terminal SP-C sequence, in dipalmitoylphosphatidylcholine (DPPC)/egg phosphatidylglycerol (7:3, w/w) by (2)H-NMR. Perturbations of lipid properties by the peptide versions were compared in samples containing chain- and headgroup-deuterated lipid (DPPC-d(62) and DPPC-d(4) respectively). Also, deuterated peptide palmitate chains were compared with those of DPPC in otherwise identical lipid-protein mixtures. Palmitoylated peptide increased average DPPC-d(62) chain orientational order slightly, particularly for temperatures spanning gel and liquid crystalline coexistence, implying penetration of palmitoylated peptide into ordered membrane. In contrast, the nonpalmitoylated peptide had a small disordering effect in this temperature range. Both peptide versions perturbed DPPC-d(4) headgroup orientation similarly, suggesting little effect of palmitoylation on the largely electrostatic peptide-headgroup interaction. Deuterated acyl chains attached to the SP-C N-terminal segment displayed a qualitatively different distribution of chain order, and lower average order, than DPPC-d(62) in the same membranes. This likely reflects local perturbation of lipid headgroup spacing by the peptide portion interacting with the bilayer near the peptide palmitate chains. This study suggests that SP-C-attached acyl chains could be important for coupling of lipid and protein motions in surfactant bilayers and monolayers, especially in the context of ordered phospholipid structures such as those potentially formed during exhalation, when stabilization of the respiratory surface by surfactant is the most crucial. | lld:pubmed |
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| pubmed-article:18502795 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18502795 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18502795 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18502795 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:18502795 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18502795 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:18502795 | pubmed:issn | 1542-0086 | lld:pubmed |
| pubmed-article:18502795 | pubmed:author | pubmed-author:AndreuDavidD | lld:pubmed |
| pubmed-article:18502795 | pubmed:author | pubmed-author:MorrowMichael... | lld:pubmed |
| pubmed-article:18502795 | pubmed:author | pubmed-author:Gonzalez-Hort... | lld:pubmed |
| pubmed-article:18502795 | pubmed:author | pubmed-author:Perez-GilJesú... | lld:pubmed |
| pubmed-article:18502795 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18502795 | pubmed:volume | 95 | lld:pubmed |
| pubmed-article:18502795 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18502795 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18502795 | pubmed:pagination | 2308-17 | lld:pubmed |
| pubmed-article:18502795 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:18502795 | pubmed:meshHeading | pubmed-meshheading:18502795... | lld:pubmed |
| pubmed-article:18502795 | pubmed:meshHeading | pubmed-meshheading:18502795... | lld:pubmed |
| pubmed-article:18502795 | pubmed:meshHeading | pubmed-meshheading:18502795... | lld:pubmed |
