| pubmed-article:18499678 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18499678 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:18499678 | lifeskim:mentions | umls-concept:C0003765 | lld:lifeskim |
| pubmed-article:18499678 | lifeskim:mentions | umls-concept:C0019652 | lld:lifeskim |
| pubmed-article:18499678 | lifeskim:mentions | umls-concept:C0079419 | lld:lifeskim |
| pubmed-article:18499678 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:18499678 | lifeskim:mentions | umls-concept:C1826517 | lld:lifeskim |
| pubmed-article:18499678 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:18499678 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:18499678 | lifeskim:mentions | umls-concept:C1554963 | lld:lifeskim |
| pubmed-article:18499678 | lifeskim:mentions | umls-concept:C0127400 | lld:lifeskim |
| pubmed-article:18499678 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:18499678 | lifeskim:mentions | umls-concept:C1363844 | lld:lifeskim |
| pubmed-article:18499678 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:18499678 | pubmed:issue | 29 | lld:pubmed |
| pubmed-article:18499678 | pubmed:dateCreated | 2008-7-14 | lld:pubmed |
| pubmed-article:18499678 | pubmed:abstractText | Protein Arg methyltransferases function as coactivators of the tumor suppressor p53 to regulate gene expression. Peptidylarginine deiminase 4 (PAD4/PADI4) counteracts the functions of protein Arg methyltransferases in gene regulation by deimination and demethylimination. Here we show that the expression of a tumor suppressor gene, OKL38, is activated by the inhibition of PAD4 or the activation of p53 following DNA damage. Chromatin immunoprecipitation assays showed a dynamic change of p53 and PAD4 occupancy and histone Arg modifications at the OKL38 promoter during DNA damage, suggesting a direct role of PAD4 and p53 in the expression of OKL38. Furthermore, we found that OKL38 induces apoptosis through localization to mitochondria and induction of cytochrome c release. Together, our studies identify OKL38 as a novel p53 target gene that is regulated by PAD4 and plays a role in apoptosis. | lld:pubmed |
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| pubmed-article:18499678 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18499678 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18499678 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18499678 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18499678 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:18499678 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18499678 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:18499678 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:18499678 | pubmed:author | pubmed-author:WangYanmingY | lld:pubmed |
| pubmed-article:18499678 | pubmed:author | pubmed-author:ThompsonPaul... | lld:pubmed |
| pubmed-article:18499678 | pubmed:author | pubmed-author:PughB... | lld:pubmed |
| pubmed-article:18499678 | pubmed:author | pubmed-author:YaoHongjieH | lld:pubmed |
| pubmed-article:18499678 | pubmed:author | pubmed-author:VentersBryan... | lld:pubmed |
| pubmed-article:18499678 | pubmed:author | pubmed-author:ZhengSutingS | lld:pubmed |
| pubmed-article:18499678 | pubmed:author | pubmed-author:LiPingxinP | lld:pubmed |
| pubmed-article:18499678 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18499678 | pubmed:day | 18 | lld:pubmed |
| pubmed-article:18499678 | pubmed:volume | 283 | lld:pubmed |
| pubmed-article:18499678 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18499678 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18499678 | pubmed:pagination | 20060-8 | lld:pubmed |
| pubmed-article:18499678 | pubmed:dateRevised | 2011-5-20 | lld:pubmed |
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