| pubmed-article:18490774 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18490774 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:18490774 | lifeskim:mentions | umls-concept:C0085243 | lld:lifeskim |
| pubmed-article:18490774 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:18490774 | lifeskim:mentions | umls-concept:C0920350 | lld:lifeskim |
| pubmed-article:18490774 | lifeskim:mentions | umls-concept:C0751781 | lld:lifeskim |
| pubmed-article:18490774 | lifeskim:mentions | umls-concept:C0205359 | lld:lifeskim |
| pubmed-article:18490774 | lifeskim:mentions | umls-concept:C0333668 | lld:lifeskim |
| pubmed-article:18490774 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:18490774 | pubmed:dateCreated | 2008-5-20 | lld:pubmed |
| pubmed-article:18490774 | pubmed:abstractText | B cells are important for the development of most autoimmune diseases. B cell depletion immunotherapy has emerged as an effective treatment for several human autoimmune diseases, although it is unclear whether B cells are necessary for disease induction, autoantibody production, or disease progression. To address the role of B cells in a murine model of spontaneous autoimmune thyroiditis (SAT), B cells were depleted from adult NOD.H-2h4 mice using anti-mouse CD20 mAb. Anti-CD20 depleted most B cells in peripheral blood and cervical lymph nodes and 50-80% of splenic B cells. Flow cytometry analysis showed that marginal zone B cells in the spleen were relatively resistant to depletion by anti-CD20, whereas most follicular and transitional (T2) B cells were depleted after anti-CD20 treatment. When anti-CD20 was administered before development of SAT, development of SAT and anti-mouse thyroglobulin autoantibody responses were reduced. Anti-CD20 also reduced SAT severity and inhibited further increases in anti-mouse thyroglobulin autoantibodies when administered to mice that already had autoantibodies and thyroid inflammation. The results suggest that B cells are necessary for initiation as well as progression or maintenance of SAT in NOD.H-2h4 mice. | lld:pubmed |
| pubmed-article:18490774 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18490774 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18490774 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:18490774 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18490774 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18490774 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18490774 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:18490774 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:18490774 | pubmed:author | pubmed-author:KehryMarilyn... | lld:pubmed |
| pubmed-article:18490774 | pubmed:author | pubmed-author:YuShiguangS | lld:pubmed |
| pubmed-article:18490774 | pubmed:author | pubmed-author:Braley-Mullen... | lld:pubmed |
| pubmed-article:18490774 | pubmed:author | pubmed-author:DunnRobertR | lld:pubmed |
| pubmed-article:18490774 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18490774 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:18490774 | pubmed:volume | 180 | lld:pubmed |
| pubmed-article:18490774 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18490774 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18490774 | pubmed:pagination | 7706-13 | lld:pubmed |
| pubmed-article:18490774 | pubmed:meshHeading | pubmed-meshheading:18490774... | lld:pubmed |
| pubmed-article:18490774 | pubmed:meshHeading | pubmed-meshheading:18490774... | lld:pubmed |
| pubmed-article:18490774 | pubmed:meshHeading | pubmed-meshheading:18490774... | lld:pubmed |
| pubmed-article:18490774 | pubmed:meshHeading | pubmed-meshheading:18490774... | lld:pubmed |
| pubmed-article:18490774 | pubmed:meshHeading | pubmed-meshheading:18490774... | lld:pubmed |
| pubmed-article:18490774 | pubmed:meshHeading | pubmed-meshheading:18490774... | lld:pubmed |
| pubmed-article:18490774 | pubmed:meshHeading | pubmed-meshheading:18490774... | lld:pubmed |
| pubmed-article:18490774 | pubmed:meshHeading | pubmed-meshheading:18490774... | lld:pubmed |
| pubmed-article:18490774 | pubmed:meshHeading | pubmed-meshheading:18490774... | lld:pubmed |
| pubmed-article:18490774 | pubmed:meshHeading | pubmed-meshheading:18490774... | lld:pubmed |
| pubmed-article:18490774 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18490774 | pubmed:articleTitle | B cell depletion inhibits spontaneous autoimmune thyroiditis in NOD.H-2h4 mice. | lld:pubmed |
| pubmed-article:18490774 | pubmed:affiliation | Research Service, Harry S. Truman Memorial Veteran's Affairs Hospital, Columbia, MO 65201, USA. | lld:pubmed |
| pubmed-article:18490774 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18490774 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:18490774 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18490774 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18490774 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18490774 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18490774 | lld:pubmed |
