| pubmed-article:18483222 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18483222 | lifeskim:mentions | umls-concept:C0054450 | lld:lifeskim |
| pubmed-article:18483222 | lifeskim:mentions | umls-concept:C0142661 | lld:lifeskim |
| pubmed-article:18483222 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:18483222 | lifeskim:mentions | umls-concept:C0663446 | lld:lifeskim |
| pubmed-article:18483222 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:18483222 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:18483222 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:18483222 | lifeskim:mentions | umls-concept:C1335240 | lld:lifeskim |
| pubmed-article:18483222 | lifeskim:mentions | umls-concept:C1419400 | lld:lifeskim |
| pubmed-article:18483222 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:18483222 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:18483222 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:18483222 | lifeskim:mentions | umls-concept:C0030685 | lld:lifeskim |
| pubmed-article:18483222 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:18483222 | lifeskim:mentions | umls-concept:C0680255 | lld:lifeskim |
| pubmed-article:18483222 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:18483222 | lifeskim:mentions | umls-concept:C1283071 | lld:lifeskim |
| pubmed-article:18483222 | lifeskim:mentions | umls-concept:C1963578 | lld:lifeskim |
| pubmed-article:18483222 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:18483222 | pubmed:dateCreated | 2008-5-16 | lld:pubmed |
| pubmed-article:18483222 | pubmed:abstractText | The positive transcription elongation factor b (P-TEFb), consisting of Cdk9 and cyclin T, stimulates RNA polymerase II elongation and cotranscriptional pre-mRNA processing. To accommodate different growth conditions and transcriptional demands, a reservoir of P-TEFb is kept in an inactive state in the multisubunit 7SK snRNP. Under certain stress or disease conditions, P-TEFb is released to activate transcription, although the signaling pathway(s) that controls this is largely unknown. Here, through analyzing the UV- or hexamethylene bisacetamide (HMBA)-induced release of P-TEFb from 7SK snRNP, an essential role for the calcium ion (Ca2+)-calmodulin-protein phosphatase 2B (PP2B) signaling pathway is revealed. However, Ca2+ signaling alone is insufficient, and PP2B must act sequentially and cooperatively with protein phosphatase 1alpha (PP1alpha) to disrupt 7SK snRNP. Activated by UV/HMBA and facilitated by a PP2B-induced conformational change in 7SK snRNP, PP1alpha releases P-TEFb through dephosphorylating phospho-Thr186 in the Cdk9 T-loop. This event is also necessary for the subsequent recruitment of P-TEFb by the bromodomain protein Brd4 to the preinitiation complex, where Cdk9 remains unphosphorylated and inactive until after the synthesis of a short RNA. Thus, through cooperatively dephosphorylating Cdk9 in response to Ca2+ signaling, PP2B and PP1alpha alter the P-TEFb functional equilibrium through releasing P-TEFb from 7SK snRNP for transcription. | lld:pubmed |
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| pubmed-article:18483222 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18483222 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18483222 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18483222 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18483222 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18483222 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18483222 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18483222 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18483222 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18483222 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18483222 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18483222 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18483222 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18483222 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18483222 | pubmed:month | May | lld:pubmed |
| pubmed-article:18483222 | pubmed:issn | 0890-9369 | lld:pubmed |
| pubmed-article:18483222 | pubmed:author | pubmed-author:ZhuYingY | lld:pubmed |
| pubmed-article:18483222 | pubmed:author | pubmed-author:LiuMinM | lld:pubmed |
| pubmed-article:18483222 | pubmed:author | pubmed-author:LiHuanH | lld:pubmed |
| pubmed-article:18483222 | pubmed:author | pubmed-author:ZhouQiangQ | lld:pubmed |
| pubmed-article:18483222 | pubmed:author | pubmed-author:ZhouNanN | lld:pubmed |
| pubmed-article:18483222 | pubmed:author | pubmed-author:ChenRuichuanR | lld:pubmed |
| pubmed-article:18483222 | pubmed:author | pubmed-author:HeNanhaiN | lld:pubmed |
| pubmed-article:18483222 | pubmed:author | pubmed-author:RameyWanichay... | lld:pubmed |
| pubmed-article:18483222 | pubmed:author | pubmed-author:LuoHaohongH | lld:pubmed |
| pubmed-article:18483222 | pubmed:author | pubmed-author:XueYuhuaY | lld:pubmed |
| pubmed-article:18483222 | pubmed:author | pubmed-author:AiNanpingN | lld:pubmed |
| pubmed-article:18483222 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18483222 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:18483222 | pubmed:volume | 22 | lld:pubmed |
| pubmed-article:18483222 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18483222 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18483222 | pubmed:pagination | 1356-68 | lld:pubmed |
| pubmed-article:18483222 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:18483222 | pubmed:meshHeading | pubmed-meshheading:18483222... | lld:pubmed |
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| pubmed-article:18483222 | pubmed:meshHeading | pubmed-meshheading:18483222... | lld:pubmed |
