| pubmed-article:18480474 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18480474 | lifeskim:mentions | umls-concept:C0019682 | lld:lifeskim |
| pubmed-article:18480474 | lifeskim:mentions | umls-concept:C0019699 | lld:lifeskim |
| pubmed-article:18480474 | lifeskim:mentions | umls-concept:C0003451 | lld:lifeskim |
| pubmed-article:18480474 | lifeskim:mentions | umls-concept:C1335268 | lld:lifeskim |
| pubmed-article:18480474 | lifeskim:mentions | umls-concept:C0220908 | lld:lifeskim |
| pubmed-article:18480474 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:18480474 | lifeskim:mentions | umls-concept:C1510438 | lld:lifeskim |
| pubmed-article:18480474 | lifeskim:mentions | umls-concept:C0243077 | lld:lifeskim |
| pubmed-article:18480474 | lifeskim:mentions | umls-concept:C1514583 | lld:lifeskim |
| pubmed-article:18480474 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:18480474 | pubmed:dateCreated | 2008-6-23 | lld:pubmed |
| pubmed-article:18480474 | pubmed:abstractText | Small-molecule inhibitors of HIV integrase (HIV IN) have emerged as a promising new class of antivirals for the treatment of HIV/AIDS. The compounds currently approved or in clinical development specifically target HIV DNA integration and were identified using strand-transfer assays targeting the HIV IN/viral DNA complex. The authors have developed a second biochemical assay for identification of HIV integrase inhibitors, targeting the interaction between HIV IN and the cellular cofactor LEDGF/p75. They developed a luminescent proximity assay (AlphaScreen) designed to measure the association of the 80-amino-acid integrase binding domain of LEDGF/p75 with the 163-amino-acid catalytic core domain of HIV IN. This assay proved to be quite robust (with a Z' factor of 0.84 in screening libraries arrayed as orthogonal mixtures) and successfully identified several compounds specific for this protein-protein interaction. | lld:pubmed |
| pubmed-article:18480474 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18480474 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18480474 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18480474 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18480474 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18480474 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18480474 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18480474 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18480474 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18480474 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:18480474 | pubmed:issn | 1087-0571 | lld:pubmed |
| pubmed-article:18480474 | pubmed:author | pubmed-author:IngravalloPau... | lld:pubmed |
| pubmed-article:18480474 | pubmed:author | pubmed-author:FeldBorisB | lld:pubmed |
| pubmed-article:18480474 | pubmed:author | pubmed-author:HoweJohn AJA | lld:pubmed |
| pubmed-article:18480474 | pubmed:author | pubmed-author:LunnCharles... | lld:pubmed |
| pubmed-article:18480474 | pubmed:author | pubmed-author:ProngayAndrew... | lld:pubmed |
| pubmed-article:18480474 | pubmed:author | pubmed-author:HouYanY | lld:pubmed |
| pubmed-article:18480474 | pubmed:author | pubmed-author:OgertRobert... | lld:pubmed |
| pubmed-article:18480474 | pubmed:author | pubmed-author:McGuinnessDeb... | lld:pubmed |
| pubmed-article:18480474 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18480474 | pubmed:volume | 13 | lld:pubmed |
| pubmed-article:18480474 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18480474 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18480474 | pubmed:pagination | 406-14 | lld:pubmed |
| pubmed-article:18480474 | pubmed:dateRevised | 2011-5-23 | lld:pubmed |
| pubmed-article:18480474 | pubmed:meshHeading | pubmed-meshheading:18480474... | lld:pubmed |
| pubmed-article:18480474 | pubmed:meshHeading | pubmed-meshheading:18480474... | lld:pubmed |
| pubmed-article:18480474 | pubmed:meshHeading | pubmed-meshheading:18480474... | lld:pubmed |
| pubmed-article:18480474 | pubmed:meshHeading | pubmed-meshheading:18480474... | lld:pubmed |
| pubmed-article:18480474 | pubmed:meshHeading | pubmed-meshheading:18480474... | lld:pubmed |
| pubmed-article:18480474 | pubmed:meshHeading | pubmed-meshheading:18480474... | lld:pubmed |
| pubmed-article:18480474 | pubmed:meshHeading | pubmed-meshheading:18480474... | lld:pubmed |
| pubmed-article:18480474 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18480474 | pubmed:articleTitle | Screening for antiviral inhibitors of the HIV integrase-LEDGF/p75 interaction using the AlphaScreen luminescent proximity assay. | lld:pubmed |
| pubmed-article:18480474 | pubmed:affiliation | Department of Virology, Schering-Plough Research Institute, Kenilworth, New Jersey 07033, USA. | lld:pubmed |
| pubmed-article:18480474 | pubmed:publicationType | Journal Article | lld:pubmed |
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