| pubmed-article:18480314 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18480314 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:18480314 | lifeskim:mentions | umls-concept:C0025260 | lld:lifeskim |
| pubmed-article:18480314 | lifeskim:mentions | umls-concept:C0019004 | lld:lifeskim |
| pubmed-article:18480314 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:18480314 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:18480314 | lifeskim:mentions | umls-concept:C2677484 | lld:lifeskim |
| pubmed-article:18480314 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:18480314 | pubmed:dateCreated | 2008-7-29 | lld:pubmed |
| pubmed-article:18480314 | pubmed:abstractText | Serologic responses to T cell-dependent vaccinations are severely attenuated in patients with ESRD, but the reasons for this is unknown. In this study, a detailed analysis of antigen-specific T cell responses was performed. Patients on hemodialysis and age- and gender-matched healthy control subjects were vaccinated with hepatitis B surface antigen (HBsAg), antigen-specific CD4(+) T cells were monitored at regular intervals with intracellular cytokine staining and proliferation assays. IL-2-and IFN-gamma-producing CD4(+) T cells were identified as either central or effector memory CD4(+) T cells using antibodies directed against CD45RO and the chemokine receptor CCR7. Control subjects mounted a memory T cell response comprising both central and effector memory CD4(+) T cells, with the central memory response occurring 1 wk before the effector memory response. IL-2(+) HBsAg-specific memory CD4(+) T cells were primarily detected within the effector population. Patients with ESRD showed a delayed response of IL-2-and IFN-gamma-producing central memory CD4(+) T cells, but their maximal responses were similar to those of control subjects. In contrast, patients with ESRD produced only 6.3% of the IL-2(+) HBsAg-specific effector memory CD4(+) T cells produced by control subjects (0.5 +/- 0.2 x 10(4)/L versus 8 +/- 3.5 x 10(4)/L; P < 0.001), and this impaired response correlated with antigen-specific T cell proliferation and anti-HBsAg IgG titers. In conclusion, the production of antigen-specific effector memory CD4(+) T cells after vaccination, which is critical to achieve an adequate humoral response, is severely impaired in patients with ESRD. | lld:pubmed |
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| pubmed-article:18480314 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18480314 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18480314 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:18480314 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18480314 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:18480314 | pubmed:issn | 1533-3450 | lld:pubmed |
| pubmed-article:18480314 | pubmed:author | pubmed-author:BetjesMichiel... | lld:pubmed |
| pubmed-article:18480314 | pubmed:author | pubmed-author:HuismanMartin... | lld:pubmed |
| pubmed-article:18480314 | pubmed:author | pubmed-author:LitjensNicoll... | lld:pubmed |
| pubmed-article:18480314 | pubmed:author | pubmed-author:van den... | lld:pubmed |
| pubmed-article:18480314 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18480314 | pubmed:volume | 19 | lld:pubmed |
| pubmed-article:18480314 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18480314 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18480314 | pubmed:pagination | 1483-90 | lld:pubmed |
| pubmed-article:18480314 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:18480314 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18480314 | pubmed:articleTitle | Impaired immune responses and antigen-specific memory CD4+ T cells in hemodialysis patients. | lld:pubmed |
| pubmed-article:18480314 | pubmed:affiliation | Department of Internal Medicine, Division of Nephrology, Erasmus Medical Center, Rotterdam, Netherlands. n.litjens@erasmusmc.nl | lld:pubmed |
| pubmed-article:18480314 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18480314 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18480314 | lld:pubmed |
