| pubmed-article:18448537 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18448537 | lifeskim:mentions | umls-concept:C0004651 | lld:lifeskim |
| pubmed-article:18448537 | lifeskim:mentions | umls-concept:C1136253 | lld:lifeskim |
| pubmed-article:18448537 | lifeskim:mentions | umls-concept:C0445803 | lld:lifeskim |
| pubmed-article:18448537 | lifeskim:mentions | umls-concept:C0017428 | lld:lifeskim |
| pubmed-article:18448537 | lifeskim:mentions | umls-concept:C0205132 | lld:lifeskim |
| pubmed-article:18448537 | pubmed:issue | 13 | lld:pubmed |
| pubmed-article:18448537 | pubmed:dateCreated | 2008-6-11 | lld:pubmed |
| pubmed-article:18448537 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18448537 | pubmed:abstractText | A myovirus-like temperate phage, PhiHAP-1, was induced with mitomycin C from a Halomonas aquamarina strain isolated from surface waters in the Gulf of Mexico. The induced cultures produced significantly more virus-like particles (VLPs) (3.73 x 10(10) VLP ml(-1)) than control cultures (3.83 x 10(7) VLP ml(-1)) when observed with epifluorescence microscopy. The induced phage was sequenced by using linker-amplified shotgun libraries and contained a genome 39,245 nucleotides in length with a G+C content of 59%. The PhiHAP-1 genome contained 46 putative open reading frames (ORFs), with 76% sharing significant similarity (E value of <10(-3)) at the protein level with other sequences in GenBank. Putative functional gene assignments included small and large terminase subunits, capsid and tail genes, an N6-DNA adenine methyltransferase, and lysogeny-related genes. Although no integrase was found, the PhiHAP-1 genome contained ORFs similar to protelomerase and parA genes found in linear plasmid-like phages with telomeric ends. Southern probing and PCR analysis of host genomic, plasmid, and PhiHAP-1 DNA indicated a lack of integration of the prophage with the host chromosome and a difference in genome arrangement between the prophage and virion forms. The linear plasmid prophage form of PhiHAP-1 begins with the protelomerase gene, presumably due to the activity of the protelomerase, while the induced phage particle has a circularly permuted genome that begins with the terminase genes. The PhiHAP-1 genome shares synteny and gene similarity with coliphage N15 and vibriophages VP882 and VHML, suggesting an evolutionary heritage from an N15-like linear plasmid prophage ancestor. | lld:pubmed |
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| pubmed-article:18448537 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18448537 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18448537 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:18448537 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18448537 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:18448537 | pubmed:issn | 1098-5514 | lld:pubmed |
| pubmed-article:18448537 | pubmed:author | pubmed-author:SegallAnca... | lld:pubmed |
| pubmed-article:18448537 | pubmed:author | pubmed-author:PaulJohn HJH | lld:pubmed |
| pubmed-article:18448537 | pubmed:author | pubmed-author:AuthementR... | lld:pubmed |
| pubmed-article:18448537 | pubmed:author | pubmed-author:MobberleyJenn... | lld:pubmed |
| pubmed-article:18448537 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18448537 | pubmed:volume | 82 | lld:pubmed |
| pubmed-article:18448537 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18448537 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18448537 | pubmed:pagination | 6618-30 | lld:pubmed |
| pubmed-article:18448537 | pubmed:dateRevised | 2010-9-22 | lld:pubmed |
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| pubmed-article:18448537 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18448537 | pubmed:articleTitle | The temperate marine phage PhiHAP-1 of Halomonas aquamarina possesses a linear plasmid-like prophage genome. | lld:pubmed |
| pubmed-article:18448537 | pubmed:affiliation | University of South Florida, College of Marine Science, 140 7th Avenue South, Saint Petersburg, FL 33701, USA. | lld:pubmed |
| pubmed-article:18448537 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18448537 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
