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pubmed-article:18445265pubmed:abstractTextKnock-down resistance (kdr) to DDT and pyrethroids in the major Afrotropical vector species, Anopheles gambiae sensu stricto, is associated with two alternative point mutations at amino acid position 1014 of the voltage-gated sodium channel gene, resulting in either a leucine-phenylalanine (L1014F), or a leucine-serine (L1014S) substitution. In An. gambiae S-form populations, the former mutation appears to be widespread in west Africa and has been recently reported from Uganda, while the latter, originally recorded in Kenya, has been recently found in Gabon, Cameroon and Equatorial Guinea. In M-form populations surveyed to date, only the L1014F mutation has been found, although less widespread and at lower frequencies than in sympatric S-form populations.lld:pubmed
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pubmed-article:18445265pubmed:articleTitleDistribution of knock-down resistance mutations in Anopheles gambiae molecular forms in west and west-central Africa.lld:pubmed
pubmed-article:18445265pubmed:affiliationIstituto Pasteur-Fondazione Cenci-Bolognetti, Università La Sapienza, Rome, Italy. federica.santolamazza@uniroma1.itlld:pubmed
pubmed-article:18445265pubmed:publicationTypeJournal Articlelld:pubmed
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