| pubmed-article:18438913 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18438913 | lifeskim:mentions | umls-concept:C0037929 | lld:lifeskim |
| pubmed-article:18438913 | lifeskim:mentions | umls-concept:C0001554 | lld:lifeskim |
| pubmed-article:18438913 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:18438913 | lifeskim:mentions | umls-concept:C0123759 | lld:lifeskim |
| pubmed-article:18438913 | lifeskim:mentions | umls-concept:C0206116 | lld:lifeskim |
| pubmed-article:18438913 | lifeskim:mentions | umls-concept:C0011306 | lld:lifeskim |
| pubmed-article:18438913 | lifeskim:mentions | umls-concept:C0599766 | lld:lifeskim |
| pubmed-article:18438913 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:18438913 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:18438913 | pubmed:dateCreated | 2008-6-23 | lld:pubmed |
| pubmed-article:18438913 | pubmed:abstractText | We have previously reported that the transplantation of dendritic cells (DCs) brings about functional recovery after spinal cord injury in mice through the activation of endogenous microglia/macrophages and neural stem/progenitor cells. In this study, the effect of interleukin-12 (IL-12), which is secreted from DCs, was evaluated for the treatment of spinal cord injury in mice. Administration of IL-12 into the injured site significantly increased the number of activated microglia/macrophages and DCs as well as the expression of brain-derived neurotrophic factor surrounding the lesion site. Immunohistochemical analyses showed that de novo neurogenesis and remyelination were induced by IL-12 treatment. Furthermore, an open field test using Basso-Beattie-Brenham scoring revealed a significant improvement of locomotor function in mice treated with IL-12. These results suggest that IL-12 administration into the injured spinal cord results in a functional recovery through the activation of microglia/macrophages and DCs. | lld:pubmed |
| pubmed-article:18438913 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18438913 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18438913 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18438913 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18438913 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18438913 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18438913 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:18438913 | pubmed:issn | 1097-4547 | lld:pubmed |
| pubmed-article:18438913 | pubmed:author | pubmed-author:YaguchiMasaeM | lld:pubmed |
| pubmed-article:18438913 | pubmed:author | pubmed-author:ToyamaYoshiak... | lld:pubmed |
| pubmed-article:18438913 | pubmed:author | pubmed-author:TodaMasahiroM | lld:pubmed |
| pubmed-article:18438913 | pubmed:author | pubmed-author:KawakamiYutak... | lld:pubmed |
| pubmed-article:18438913 | pubmed:author | pubmed-author:OhtaShigekiS | lld:pubmed |
| pubmed-article:18438913 | pubmed:copyrightInfo | 2008 Wiley-Liss, Inc. | lld:pubmed |
| pubmed-article:18438913 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18438913 | pubmed:volume | 86 | lld:pubmed |
| pubmed-article:18438913 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18438913 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18438913 | pubmed:pagination | 1972-80 | lld:pubmed |
| pubmed-article:18438913 | pubmed:meshHeading | pubmed-meshheading:18438913... | lld:pubmed |
| pubmed-article:18438913 | pubmed:meshHeading | pubmed-meshheading:18438913... | lld:pubmed |
| pubmed-article:18438913 | pubmed:meshHeading | pubmed-meshheading:18438913... | lld:pubmed |
| pubmed-article:18438913 | pubmed:meshHeading | pubmed-meshheading:18438913... | lld:pubmed |
| pubmed-article:18438913 | pubmed:meshHeading | pubmed-meshheading:18438913... | lld:pubmed |
| pubmed-article:18438913 | pubmed:meshHeading | pubmed-meshheading:18438913... | lld:pubmed |
| pubmed-article:18438913 | pubmed:meshHeading | pubmed-meshheading:18438913... | lld:pubmed |
| pubmed-article:18438913 | pubmed:meshHeading | pubmed-meshheading:18438913... | lld:pubmed |
| pubmed-article:18438913 | pubmed:meshHeading | pubmed-meshheading:18438913... | lld:pubmed |
| pubmed-article:18438913 | pubmed:meshHeading | pubmed-meshheading:18438913... | lld:pubmed |
| pubmed-article:18438913 | pubmed:meshHeading | pubmed-meshheading:18438913... | lld:pubmed |
| pubmed-article:18438913 | pubmed:meshHeading | pubmed-meshheading:18438913... | lld:pubmed |
| pubmed-article:18438913 | pubmed:meshHeading | pubmed-meshheading:18438913... | lld:pubmed |
| pubmed-article:18438913 | pubmed:meshHeading | pubmed-meshheading:18438913... | lld:pubmed |
| pubmed-article:18438913 | pubmed:meshHeading | pubmed-meshheading:18438913... | lld:pubmed |
| pubmed-article:18438913 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18438913 | pubmed:articleTitle | Functional recovery after spinal cord injury in mice through activation of microglia and dendritic cells after IL-12 administration. | lld:pubmed |
| pubmed-article:18438913 | pubmed:affiliation | Neuroimmunology Research Group, Keio University School of Medicine, Tokyo, Japan. | lld:pubmed |
| pubmed-article:18438913 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18438913 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18438913 | lld:pubmed |
