| pubmed-article:18424136 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18424136 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:18424136 | lifeskim:mentions | umls-concept:C0935929 | lld:lifeskim |
| pubmed-article:18424136 | lifeskim:mentions | umls-concept:C0053169 | lld:lifeskim |
| pubmed-article:18424136 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:18424136 | pubmed:dateCreated | 2008-5-5 | lld:pubmed |
| pubmed-article:18424136 | pubmed:abstractText | N-(6-Substituted-1,3-benzothiazol-2-yl)benzenesulfonamide derivatives 1-8 were synthesized and evaluated for their in vivo antidiabetic activity in a non-insulin-dependent diabetes mellitus rat model. Several compounds synthesized showed significant lowering of plasma glucose level in this model. As a possible mode of action, the compounds were in vitro evaluated as 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) inhibitors. The most active compounds (3 and 4) were docked into the crystal structure of 11beta-HSD1. Docking results indicate potential hydrogen bond interactions with catalytic amino acid residues. | lld:pubmed |
| pubmed-article:18424136 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18424136 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18424136 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18424136 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18424136 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18424136 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18424136 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18424136 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18424136 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18424136 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18424136 | pubmed:month | May | lld:pubmed |
| pubmed-article:18424136 | pubmed:issn | 1464-3405 | lld:pubmed |
| pubmed-article:18424136 | pubmed:author | pubmed-author:WebsterScott... | lld:pubmed |
| pubmed-article:18424136 | pubmed:author | pubmed-author:Navarrete-Váz... | lld:pubmed |
| pubmed-article:18424136 | pubmed:author | pubmed-author:Villalobos-Mo... | lld:pubmed |
| pubmed-article:18424136 | pubmed:author | pubmed-author:Medina-Franco... | lld:pubmed |
| pubmed-article:18424136 | pubmed:author | pubmed-author:Estrada-SotoS... | lld:pubmed |
| pubmed-article:18424136 | pubmed:author | pubmed-author:Moreno-DíazHe... | lld:pubmed |
| pubmed-article:18424136 | pubmed:author | pubmed-author:León-RiveraIs... | lld:pubmed |
| pubmed-article:18424136 | pubmed:author | pubmed-author:BinnieMargare... | lld:pubmed |
| pubmed-article:18424136 | pubmed:author | pubmed-author:Ortiz-Andrade... | lld:pubmed |
| pubmed-article:18424136 | pubmed:author | pubmed-author:Díaz-CoutiñoD... | lld:pubmed |
| pubmed-article:18424136 | pubmed:author | pubmed-author:Ibarra-Baraja... | lld:pubmed |
| pubmed-article:18424136 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18424136 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:18424136 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:18424136 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18424136 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18424136 | pubmed:pagination | 2871-7 | lld:pubmed |
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| pubmed-article:18424136 | pubmed:meshHeading | pubmed-meshheading:18424136... | lld:pubmed |
| pubmed-article:18424136 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18424136 | pubmed:articleTitle | Antidiabetic activity of N-(6-substituted-1,3-benzothiazol-2-yl)benzenesulfonamides. | lld:pubmed |
| pubmed-article:18424136 | pubmed:affiliation | Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, Cuernavaca, Morelos 62209, Mexico. | lld:pubmed |
| pubmed-article:18424136 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18424136 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:18424136 | lld:chembl |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18424136 | lld:pubmed |
