| pubmed-article:18418249 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18418249 | lifeskim:mentions | umls-concept:C0206745 | lld:lifeskim |
| pubmed-article:18418249 | lifeskim:mentions | umls-concept:C0026455 | lld:lifeskim |
| pubmed-article:18418249 | lifeskim:mentions | umls-concept:C0678939 | lld:lifeskim |
| pubmed-article:18418249 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:18418249 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:18418249 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:18418249 | pubmed:dateCreated | 2008-4-17 | lld:pubmed |
| pubmed-article:18418249 | pubmed:abstractText | A novel line of mutant mice [monoamine oxidase A knockout (MAOA KO)] harboring a spontaneous point nonsense mutation in exon 8 of the MAO A gene was serendipitously identified in a 129/SvEvTac colony. This mutation is analogous to the cause of a rare human disorder, Brunner syndrome, characterized by complete MAO A deficiency and impulsive aggressiveness. Concurrent with previous studies of MAO A KO mice generated by insertional mutagenesis ('Tg8'), MAOA(A863T) KO lack MAO A enzyme activity and display enhanced aggression toward intruder mice. MAOA(A863T) KO, however, exhibited lower locomotor activity in a novel, inescapable open field and similar immobility during tail suspension compared with wild type, observations which differ from reports of Tg8. These findings consolidate evidence linking MAO A to aggression and highlight subtle yet distinctive phenotypical characteristics. | lld:pubmed |
| pubmed-article:18418249 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18418249 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18418249 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18418249 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18418249 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18418249 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18418249 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18418249 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18418249 | pubmed:month | May | lld:pubmed |
| pubmed-article:18418249 | pubmed:issn | 0959-4965 | lld:pubmed |
| pubmed-article:18418249 | pubmed:author | pubmed-author:ChenKevinK | lld:pubmed |
| pubmed-article:18418249 | pubmed:author | pubmed-author:ShihJean CJC | lld:pubmed |
| pubmed-article:18418249 | pubmed:author | pubmed-author:BortolatoMarc... | lld:pubmed |
| pubmed-article:18418249 | pubmed:author | pubmed-author:ScottAnna LAL | lld:pubmed |
| pubmed-article:18418249 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18418249 | pubmed:day | 7 | lld:pubmed |
| pubmed-article:18418249 | pubmed:volume | 19 | lld:pubmed |
| pubmed-article:18418249 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18418249 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18418249 | pubmed:pagination | 739-43 | lld:pubmed |
| pubmed-article:18418249 | pubmed:meshHeading | pubmed-meshheading:18418249... | lld:pubmed |
| pubmed-article:18418249 | pubmed:meshHeading | pubmed-meshheading:18418249... | lld:pubmed |
| pubmed-article:18418249 | pubmed:meshHeading | pubmed-meshheading:18418249... | lld:pubmed |
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| pubmed-article:18418249 | pubmed:meshHeading | pubmed-meshheading:18418249... | lld:pubmed |
| pubmed-article:18418249 | pubmed:meshHeading | pubmed-meshheading:18418249... | lld:pubmed |
| pubmed-article:18418249 | pubmed:meshHeading | pubmed-meshheading:18418249... | lld:pubmed |
| pubmed-article:18418249 | pubmed:meshHeading | pubmed-meshheading:18418249... | lld:pubmed |
| pubmed-article:18418249 | pubmed:meshHeading | pubmed-meshheading:18418249... | lld:pubmed |
| pubmed-article:18418249 | pubmed:meshHeading | pubmed-meshheading:18418249... | lld:pubmed |
| pubmed-article:18418249 | pubmed:meshHeading | pubmed-meshheading:18418249... | lld:pubmed |
| pubmed-article:18418249 | pubmed:meshHeading | pubmed-meshheading:18418249... | lld:pubmed |
| pubmed-article:18418249 | pubmed:meshHeading | pubmed-meshheading:18418249... | lld:pubmed |
| pubmed-article:18418249 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18418249 | pubmed:articleTitle | Novel monoamine oxidase A knock out mice with human-like spontaneous mutation. | lld:pubmed |
| pubmed-article:18418249 | pubmed:affiliation | Department of Pharmacology and Pharmaceutical Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA. | lld:pubmed |
| pubmed-article:18418249 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18418249 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:17161 | entrezgene:pubmed | pubmed-article:18418249 | lld:entrezgene |
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