| pubmed-article:1841476 | pubmed:abstractText | At present neonatal coccidiosis caused by Isospora suis is known to be an important disease in piglets. The coccidium I. suis was diagnosed as the causative agent of diarrhoeic disease in piglets on a large pig farm with continuous farrowing operation. The diagnosis of coccidiosis was based on clinical history, gross lesions, histopathology, stained impression smears and aided by detection of oocysts in the faeces. Coccidiosis was associated with diarrhoea in piglets at the age of five to fourteen days. The disease was characterized by variable morbidity and only a portion of the litters was usually affected at one time. The piglets appeared listless, and suffered from yellow watery scours progressing to yellow pasty scours over a three- to five-day period. The lack of response to common antimicrobial therapy, and/or vaccination of sows for E. coli was observed. The prophylactic and therapeutic efficacy of tortrazuril (Baycox, Bayer) against coccidiosis was evaluated in naturally infected piglets. Tortrazuril at a dose of 20 mg/kg, given perorally to each piglet on days 6 and 8 of age, proved to be efficacious in preventing clinical coccidiosis in piglets. Tortrazuril fully controlled the oocyst output, prevented the development of diarrhoea but not improved the weight gains in three-week-old piglets if compared to the untreated controls. The prophylactic and therapeutic efficacy of tortrazuril was compared with another drug--amprolium (Amprovin, MSD). Amprolium at a dose of 100 mg/kg, given perorally to piglets from day 6 to 8 of age, was not efficacious in preventing clinical porcine neonatal coccidiosis. Amprolium reduced the oocyst output, but not prevented the development of diarrhoea. Tortrazuril (Baycox, Bayer) is clearly effective against porcine neonatal coccidiosis caused by I. suis. | lld:pubmed |
