| pubmed-article:18394421 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18394421 | lifeskim:mentions | umls-concept:C0030567 | lld:lifeskim |
| pubmed-article:18394421 | lifeskim:mentions | umls-concept:C0027934 | lld:lifeskim |
| pubmed-article:18394421 | lifeskim:mentions | umls-concept:C1545588 | lld:lifeskim |
| pubmed-article:18394421 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:18394421 | lifeskim:mentions | umls-concept:C0071649 | lld:lifeskim |
| pubmed-article:18394421 | lifeskim:mentions | umls-concept:C1522492 | lld:lifeskim |
| pubmed-article:18394421 | lifeskim:mentions | umls-concept:C0136157 | lld:lifeskim |
| pubmed-article:18394421 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:18394421 | pubmed:dateCreated | 2008-8-4 | lld:pubmed |
| pubmed-article:18394421 | pubmed:abstractText | Mechanisms of nigral cell injury in Parkinson's disease remain unclear, although a combination of increased oxidative stress, the formation of catecholamine-quinones and the subsequent formation of neurotoxic cysteinyl-catecholamine conjugates may contribute. In the present study, peroxynitrite was observed to generate both 2-S- and 5-S-cysteinyl-dopamine and a dihydrobenzothiazine species, DHBT-1, following the reaction of dopamine with l-cysteine. The formation of 5-S-cysteinyl-dopamine and DHBT-1 in the presence of peroxynitrite induced significant neuronal injury. Pre-treatment of cortical neurons with pelargonidin, quercetin, hesperetin, caffeic acid, the 4'-O-Me derivatives of catechin and epicatechin (0.1-3.0 microM) resulted in concentration dependant protection against 5-S-cysteinyl-dopamine-induced neurotoxicity. These data suggest that polyphenols may protect against neuronal injury induced by endogenous neurotoxins relevant to the aetiology of the Parkinson disease. | lld:pubmed |
| pubmed-article:18394421 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18394421 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18394421 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18394421 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18394421 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18394421 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18394421 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18394421 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18394421 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18394421 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18394421 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18394421 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18394421 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:18394421 | pubmed:issn | 1096-0384 | lld:pubmed |
| pubmed-article:18394421 | pubmed:author | pubmed-author:SpencerJeremy... | lld:pubmed |
| pubmed-article:18394421 | pubmed:author | pubmed-author:AngeloniCrist... | lld:pubmed |
| pubmed-article:18394421 | pubmed:author | pubmed-author:VauzourDavidD | lld:pubmed |
| pubmed-article:18394421 | pubmed:author | pubmed-author:VafeiadouKate... | lld:pubmed |
| pubmed-article:18394421 | pubmed:author | pubmed-author:Rodriguez-Mat... | lld:pubmed |
| pubmed-article:18394421 | pubmed:author | pubmed-author:RavaioliGiuli... | lld:pubmed |
| pubmed-article:18394421 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18394421 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:18394421 | pubmed:volume | 476 | lld:pubmed |
| pubmed-article:18394421 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18394421 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18394421 | pubmed:pagination | 145-51 | lld:pubmed |
| pubmed-article:18394421 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:18394421 | pubmed:meshHeading | pubmed-meshheading:18394421... | lld:pubmed |
| pubmed-article:18394421 | pubmed:meshHeading | pubmed-meshheading:18394421... | lld:pubmed |
| pubmed-article:18394421 | pubmed:meshHeading | pubmed-meshheading:18394421... | lld:pubmed |
| pubmed-article:18394421 | pubmed:meshHeading | pubmed-meshheading:18394421... | lld:pubmed |
| pubmed-article:18394421 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18394421 | pubmed:articleTitle | Peroxynitrite induced formation of the neurotoxins 5-S-cysteinyl-dopamine and DHBT-1: implications for Parkinson's disease and protection by polyphenols. | lld:pubmed |
| pubmed-article:18394421 | pubmed:affiliation | Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, The University of Reading, P.O. Box 226, Whiteknights Campus, Reading RG6 6AP, UK. | lld:pubmed |
| pubmed-article:18394421 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18394421 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18394421 | lld:pubmed |
