| pubmed-article:18390836 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18390836 | lifeskim:mentions | umls-concept:C0022688 | lld:lifeskim |
| pubmed-article:18390836 | lifeskim:mentions | umls-concept:C1235660 | lld:lifeskim |
| pubmed-article:18390836 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:18390836 | lifeskim:mentions | umls-concept:C0212320 | lld:lifeskim |
| pubmed-article:18390836 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:18390836 | lifeskim:mentions | umls-concept:C0815089 | lld:lifeskim |
| pubmed-article:18390836 | lifeskim:mentions | umls-concept:C2348235 | lld:lifeskim |
| pubmed-article:18390836 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:18390836 | pubmed:dateCreated | 2008-7-24 | lld:pubmed |
| pubmed-article:18390836 | pubmed:abstractText | CBFbeta is the non-DNA binding subunit of the core binding factors (CBFs). Mice with reduced CBFbeta levels display profound, early defects in T-cell but not B-cell development. Here we show that CBFbeta is also required at very early stages of natural killer (NK)-cell development. We also demonstrate that T-cell development aborts during specification, as the expression of Gata3 and Tcf7, which encode key regulators of T lineage specification, is substantially reduced, as are functional thymic progenitors. Constitutively active Notch or IL-7 signaling cannot restore T-cell expansion or differentiation of CBFbeta insufficient cells, nor can overexpression of Runx1 or CBFbeta overcome a lack of Notch signaling. Therefore, the ability of the prethymic cell to respond appropriately to Notch is dependent on CBFbeta, and both signals converge to activate the T-cell developmental program. | lld:pubmed |
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| pubmed-article:18390836 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18390836 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18390836 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:18390836 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:18390836 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18390836 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:18390836 | pubmed:issn | 1528-0020 | lld:pubmed |
| pubmed-article:18390836 | pubmed:author | pubmed-author:YaghiO YOY | lld:pubmed |
| pubmed-article:18390836 | pubmed:author | pubmed-author:RothenbergEll... | lld:pubmed |
