| pubmed-article:18387740 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18387740 | lifeskim:mentions | umls-concept:C0003289 | lld:lifeskim |
| pubmed-article:18387740 | lifeskim:mentions | umls-concept:C0034838 | lld:lifeskim |
| pubmed-article:18387740 | lifeskim:mentions | umls-concept:C0025193 | lld:lifeskim |
| pubmed-article:18387740 | lifeskim:mentions | umls-concept:C0205419 | lld:lifeskim |
| pubmed-article:18387740 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:18387740 | pubmed:dateCreated | 2008-4-21 | lld:pubmed |
| pubmed-article:18387740 | pubmed:abstractText | Previous studies on the effects of serotonin receptor 1A (5-HT1A) gene variation on treatment response in depression revealed inconsistent results with studies pointing towards a detrimental influence of the 5-HT1A-1019G allele on antidepressant treatment response, while others did not discern any involvement of 5-HT1A variants. In order to further delineate the impact of 5-HT1A gene variation on pharmacoresponse in depression over 6 weeks of antidepressant treatment, the influence of the 5-HT1A-1019C/G (rs6295) polymorphism was investigated in 340 Caucasian patients with a Major Depressive Episode (DSM-IV) with particular attention to the subtype of depression (major depression and melancholic depression). Antidepressant treatment response across 5-HT1A-1019C/G genotype groups showed no differences in either Major Depressive Episode or major depression between genotype groups, whereas stratification for the melancholic subtype of depression revealed a significantly worse treatment response as conferred by the -1019CC genotype (p=0.02). The poorer treatment response in melancholic depression could first be detected in week 2 (p=0.03), continuing until week 6 and showing a maximum effect in week 3 (p=0.01). The present study adds to the clarification of the role of 5-HT1A variation in treatment response in major depression by providing preliminary support for poor treatment response mediated by the 5-HT1A-1019C allele repressing 5-HT1A activity specifically in the melancholic subtype of depression. | lld:pubmed |
| pubmed-article:18387740 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18387740 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18387740 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:18387740 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18387740 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18387740 | pubmed:month | May | lld:pubmed |
| pubmed-article:18387740 | pubmed:issn | 0304-3940 | lld:pubmed |
| pubmed-article:18387740 | pubmed:author | pubmed-author:RoehrsTT | lld:pubmed |
| pubmed-article:18387740 | pubmed:author | pubmed-author:DeckertJJ | lld:pubmed |
| pubmed-article:18387740 | pubmed:author | pubmed-author:AroltVV | lld:pubmed |
| pubmed-article:18387740 | pubmed:author | pubmed-author:HohoffCC | lld:pubmed |
| pubmed-article:18387740 | pubmed:author | pubmed-author:BauneB TBT | lld:pubmed |
| pubmed-article:18387740 | pubmed:author | pubmed-author:DomschkeKK | lld:pubmed |
| pubmed-article:18387740 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18387740 | pubmed:day | 9 | lld:pubmed |
| pubmed-article:18387740 | pubmed:volume | 436 | lld:pubmed |
| pubmed-article:18387740 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18387740 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18387740 | pubmed:pagination | 111-5 | lld:pubmed |
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| pubmed-article:18387740 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18387740 | pubmed:articleTitle | Serotonin receptor 1A-1019C/G variant: impact on antidepressant pharmacoresponse in melancholic depression? | lld:pubmed |
| pubmed-article:18387740 | pubmed:affiliation | Department of Psychiatry, School of Medicine, James Cook University, Queensland 4811, Australia. bernhard.baune@jcu.edu.au | lld:pubmed |
| pubmed-article:18387740 | pubmed:publicationType | Journal Article | lld:pubmed |
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