| pubmed-article:18387504 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18387504 | lifeskim:mentions | umls-concept:C0027059 | lld:lifeskim |
| pubmed-article:18387504 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:18387504 | lifeskim:mentions | umls-concept:C0018787 | lld:lifeskim |
| pubmed-article:18387504 | lifeskim:mentions | umls-concept:C0443146 | lld:lifeskim |
| pubmed-article:18387504 | lifeskim:mentions | umls-concept:C0599896 | lld:lifeskim |
| pubmed-article:18387504 | lifeskim:mentions | umls-concept:C1522326 | lld:lifeskim |
| pubmed-article:18387504 | lifeskim:mentions | umls-concept:C1292734 | lld:lifeskim |
| pubmed-article:18387504 | lifeskim:mentions | umls-concept:C1517004 | lld:lifeskim |
| pubmed-article:18387504 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:18387504 | pubmed:dateCreated | 2008-4-4 | lld:pubmed |
| pubmed-article:18387504 | pubmed:abstractText | We evaluated the efficacy of the Ligand Epitope Antigen Presentation System (L.E.A.P.S.trade mark) in preventing or treating experimental autoimmune myocarditis (EAM) in A/J mice. L.E.A.P.S. (here, J-My-1) is a conjugate of the myocarditogenic peptide of cardiac myosin MyHCalpha(334-352) (My-1) and J peptide, derived from the sequence of human beta-2 microglobulin. Remarkably, early prophylactic (J-My-1 injected on days -14 and -7 before EAM induction), late prophylactic (J-My-1 injected on days 0, 7, 14, and 21), and therapeutic (J-My-1 injected on days 7, 14, and 21 or 10, 17 and 24) administration of J-My-1 significantly decreased the incidence and severity of EAM. However, extended therapeutic treatment was associated with anaphylaxis and death, corresponding with global immune activation associated with J-My-1 treatment. In J-My1-treated animals, we observed expanded numbers of activated CD69+ and CD44+ CD4+ and CD8+ T cells in the spleens. J-My-1 treatment also increased the proportion of CD11c+ dendritic cells in spleens and induced strong production of anti-J-My-1 specific antibodies. J-My-1 injections resulted in decreased levels of chemokines MIP-1alpha and IP-10 in hearts. We propose that J-My-1 treatment interferes with trafficking of autoaggressive immune cells to the heart. | lld:pubmed |
| pubmed-article:18387504 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18387504 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18387504 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18387504 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18387504 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18387504 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18387504 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18387504 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18387504 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18387504 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18387504 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18387504 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18387504 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18387504 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18387504 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18387504 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18387504 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18387504 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18387504 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18387504 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18387504 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18387504 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18387504 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18387504 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18387504 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18387504 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18387504 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18387504 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18387504 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18387504 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18387504 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18387504 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18387504 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18387504 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18387504 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18387504 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18387504 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18387504 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18387504 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18387504 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18387504 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18387504 | pubmed:month | May | lld:pubmed |
| pubmed-article:18387504 | pubmed:issn | 1567-5769 | lld:pubmed |
| pubmed-article:18387504 | pubmed:author | pubmed-author:RoseNoel RNR | lld:pubmed |
| pubmed-article:18387504 | pubmed:author | pubmed-author:ZimmermanDani... | lld:pubmed |
| pubmed-article:18387504 | pubmed:author | pubmed-author:KimuraMihoM | lld:pubmed |
| pubmed-article:18387504 | pubmed:author | pubmed-author:BarinJobert... | lld:pubmed |
| pubmed-article:18387504 | pubmed:author | pubmed-author:TalorMonica... | lld:pubmed |
| pubmed-article:18387504 | pubmed:author | pubmed-author:TalorEyalE | lld:pubmed |
| pubmed-article:18387504 | pubmed:author | pubmed-author:CihakovaDanie... | lld:pubmed |
| pubmed-article:18387504 | pubmed:author | pubmed-author:BaldevianoG... | lld:pubmed |
| pubmed-article:18387504 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18387504 | pubmed:volume | 8 | lld:pubmed |
| pubmed-article:18387504 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18387504 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18387504 | pubmed:pagination | 624-33 | lld:pubmed |
| pubmed-article:18387504 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:18387504 | pubmed:meshHeading | pubmed-meshheading:18387504... | lld:pubmed |
| pubmed-article:18387504 | pubmed:meshHeading | pubmed-meshheading:18387504... | lld:pubmed |
| pubmed-article:18387504 | pubmed:meshHeading | pubmed-meshheading:18387504... | lld:pubmed |
| pubmed-article:18387504 | pubmed:meshHeading | pubmed-meshheading:18387504... | lld:pubmed |
| pubmed-article:18387504 | pubmed:meshHeading | pubmed-meshheading:18387504... | lld:pubmed |
| pubmed-article:18387504 | pubmed:meshHeading | pubmed-meshheading:18387504... | lld:pubmed |
| pubmed-article:18387504 | pubmed:meshHeading | pubmed-meshheading:18387504... | lld:pubmed |
| pubmed-article:18387504 | pubmed:meshHeading | pubmed-meshheading:18387504... | lld:pubmed |
| pubmed-article:18387504 | pubmed:meshHeading | pubmed-meshheading:18387504... | lld:pubmed |
| pubmed-article:18387504 | pubmed:meshHeading | pubmed-meshheading:18387504... | lld:pubmed |
| pubmed-article:18387504 | pubmed:meshHeading | pubmed-meshheading:18387504... | lld:pubmed |
| pubmed-article:18387504 | pubmed:meshHeading | pubmed-meshheading:18387504... | lld:pubmed |
| pubmed-article:18387504 | pubmed:meshHeading | pubmed-meshheading:18387504... | lld:pubmed |
| pubmed-article:18387504 | pubmed:meshHeading | pubmed-meshheading:18387504... | lld:pubmed |
| pubmed-article:18387504 | pubmed:meshHeading | pubmed-meshheading:18387504... | lld:pubmed |
| pubmed-article:18387504 | pubmed:meshHeading | pubmed-meshheading:18387504... | lld:pubmed |
| pubmed-article:18387504 | pubmed:meshHeading | pubmed-meshheading:18387504... | lld:pubmed |
| pubmed-article:18387504 | pubmed:meshHeading | pubmed-meshheading:18387504... | lld:pubmed |
| pubmed-article:18387504 | pubmed:meshHeading | pubmed-meshheading:18387504... | lld:pubmed |
| pubmed-article:18387504 | pubmed:meshHeading | pubmed-meshheading:18387504... | lld:pubmed |
| pubmed-article:18387504 | pubmed:meshHeading | pubmed-meshheading:18387504... | lld:pubmed |
| pubmed-article:18387504 | pubmed:meshHeading | pubmed-meshheading:18387504... | lld:pubmed |
| pubmed-article:18387504 | pubmed:meshHeading | pubmed-meshheading:18387504... | lld:pubmed |
| pubmed-article:18387504 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18387504 | pubmed:articleTitle | L.E.A.P.S. heteroconjugate is able to prevent and treat experimental autoimmune myocarditis by altering trafficking of autoaggressive cells to the heart. | lld:pubmed |
| pubmed-article:18387504 | pubmed:affiliation | Department of Pathology, the Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. dcihako1@jhmi.edu <dcihako1@jhmi.edu> | lld:pubmed |
| pubmed-article:18387504 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18387504 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
